Assessment of Different Threshold Preoperative Glomerular Filtration Rates as Markers of Outcomes in Lung Transplantation Asishana A. Osho, MPH, Anthony.

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Presentation transcript:

Assessment of Different Threshold Preoperative Glomerular Filtration Rates as Markers of Outcomes in Lung Transplantation Asishana A. Osho, MPH, Anthony W. Castleberry, MD, MMCi, Laurie D. Snyder, MD, MHS, Asvin M. Ganapathi, MD, Sameer A. Hirji, BS, Mark Stafford-Smith, MD, Shu S. Lin, MD, PhD, R. Duane Davis, MD, MBA, Matthew G. Hartwig, MD The Annals of Thoracic Surgery Volume 98, Issue 1, Pages 283-290 (July 2014) DOI: 10.1016/j.athoracsur.2014.03.010 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Kaplan-Meier analysis of survival to 2 years, stratified by GFR above or below specified cutoffs. (A) Cutoff, 50.0 mL/min per 1.73 m2 (historical); (B) Cutoff, 48.0 mL/min per 1.73 m2 (recursive); (C) Cutoff, 77.8 mL/min per 1.73 m2 (receiver operating characteristic, ROC). We observed significant differences in mortality on either side of the historic and recursive partitioning cutoffs. The ROC established cutoff did not generate groups with differing mortality. (CI = confidence interval; HR = hazard ratio.) The Annals of Thoracic Surgery 2014 98, 283-290DOI: (10.1016/j.athoracsur.2014.03.010) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Receiver operating characteristics (ROC) curves displaying the sorting efficiency of Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate (GFR) for predicting post-lung transplant mortality at 1 year. The GFR value that maximizes the sum of sensitivity and specificity (ie, the ideal cutoff GFR values by the receiver operating characteristics method) is reported along with area under the curve (AUC). (CI = confidence interval.) The Annals of Thoracic Surgery 2014 98, 283-290DOI: (10.1016/j.athoracsur.2014.03.010) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions