Human embryo fragmentation in vitro and its implications for pregnancy and implantation  Mina Alikani, Jacques Cohen, Ph.D., Giles Tomkin, B.A., G.John Garrisi, Ph.D., Caryn Mack, M.S., Richard T Scott, M.D.  Fertility and Sterility  Volume 71, Issue 5, Pages 836-842 (May 1999) DOI: 10.1016/S0015-0282(99)00092-8

FIGURE 1 Day 3 fragmented human embryos with fragmentation patterns I, II, III, IV, and V. Left: Embryos on day 3 of development before assisted hatching and fragment removal. Right: The same embryos after assisted hatching and fragment removal. Note distinct differences among the organization and appearance of the remaining blastomeres after removal of different types of fragments. Fertility and Sterility 1999 71, 836-842DOI: (10.1016/S0015-0282(99)00092-8)

FIGURE 2 The percentage of fragments removed from fragmented embryos versus the degree of fragmentation (in percent). The highly fragmented embryos had the most fragments removed. Fertility and Sterility 1999 71, 836-842DOI: (10.1016/S0015-0282(99)00092-8)

FIGURE 3 The incidence of implantation in transfer groups T2 (■), T3 (▴), and T4 (X) compared with implantation of embryos according to the degree of fragmentation and without consideration of the pattern of fragmentation (○). Homogeneous transfer of type IV fragmented embryos led to the lowest rate of implantation. Fertility and Sterility 1999 71, 836-842DOI: (10.1016/S0015-0282(99)00092-8)