Esomeprazole Versus Other Proton Pump Inhibitors in Erosive Esophagitis: A Meta- Analysis of Randomized Clinical Trials  Ian M. Gralnek, Gareth S. Dulai, M. Brian Fennerty, Brennan M.R. Spiegel  Clinical Gastroenterology and Hepatology  Volume 4, Issue 12, Pages 1452-1458 (December 2006) DOI: 10.1016/j.cgh.2006.09.013 Copyright © 2006 AGA Institute Terms and Conditions

Figure 1 Results of literature search. Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions

Figure 2 Relative risk reduction forest plot (random effects model) demonstrating healing of erosive esophagitis at 4 weeks (n = 14,779). Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions

Figure 3 Relative risk reduction forest plot (random effects model) demonstrating healing of erosive esophagitis at 8 weeks (n = 15,099). Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions

Figure 4 Absolute risk reduction forest plot in healing of erosive esophagitis at 8 weeks (n = 15,099). ARR = 4% yielding an NNT = 25. Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions

Figure 5 NNTs for Los Angeles grades A-D. NNTs decrease as LA Grade severity of EE increases. Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions

Figure 6 GERD symptom relief at 4 weeks: esomeprazole vs comparator PPIs relative risk forest plot with fixed effects model, n = 14,996. Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions

Figure 7 Begg’s funnel plot of studies reporting EE healing at 8 weeks selected for meta-analysis. No evidence of publication bias, P = .21 by Egger’s test, n = 15,099. Clinical Gastroenterology and Hepatology 2006 4, 1452-1458DOI: (10.1016/j.cgh.2006.09.013) Copyright © 2006 AGA Institute Terms and Conditions