Close Encounters of the Tertiary Kind

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Close Encounters of the Tertiary Kind Victoria Lee, Peter A. Savage  Immunity  Volume 43, Issue 3, Pages 418-420 (September 2015) DOI: 10.1016/j.immuni.2015.08.022 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Treg Cells Actively Restrain Effector T Cells within Tumor-Associated Tertiary Lymphoid Structures (Top) Treg cells associated with lung adenocarcinomas in “KP” mice are localized within tertiary lymphoid structures (TLSs) positioned at the tumor margin. These structures contain dendritic cells, CD4+ and CD8+ conventional T cells, regulatory T (Treg) cells, B cells, and high endothelial venules (HEVs). (Bottom) Local ablation of Treg cells triggers effector T cell activation in the TLS, infiltration of T cells into the tumor, and destruction of tumor architecture. Immunity 2015 43, 418-420DOI: (10.1016/j.immuni.2015.08.022) Copyright © 2015 Elsevier Inc. Terms and Conditions

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