A New Essential Hypertension Susceptibility Locus on Chromosome 2p24-p25, Detected by Genomewide Search Andrea Angius, Enrico Petretto, Giovanni Battista.

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A New Essential Hypertension Susceptibility Locus on Chromosome 2p24-p25, Detected by Genomewide Search Andrea Angius, Enrico Petretto, Giovanni Battista Maestrale, Paola Forabosco, Giuseppina Casu, Daniela Piras, Manuela Fanciulli, Mario Falchi, Paola Maria Melis, Mario Palermo, Mario Pirastu The American Journal of Human Genetics Volume 71, Issue 4, Pages 893-905 (October 2002) DOI: 10.1086/342929 Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Twelve-generation pedigree used in the linkage and Simwalk2 analyses. Because of computational constraints, the pedigree was broken into four smaller branches, as indicated in the figure. Family members analyzed in stage I are indicated by arrows. Blackened symbols denote affected individuals. The American Journal of Human Genetics 2002 71, 893-905DOI: (10.1086/342929) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 2 Nonparametric statistics estimated by SimWalk2 (Sobel and Lange 1996). Statistic A is the number of different founder alleles contributing alleles to the affected individuals. Statistic B is the maximum number of alleles among the affected individuals descended from any one founder allele. Statistic C is the “entropy” of the marker alleles among the affected individuals. Statistic D is the extent of allele sharing among all affected pairs, as measured by their IBD kinship coefficient. Statistic E is the “NPL_all” statistic, as implemented in GeneHunter. The American Journal of Human Genetics 2002 71, 893-905DOI: (10.1086/342929) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 3 Statistic D results for each analyzed branch of the pedigree in the whole region shown in figure 2 The American Journal of Human Genetics 2002 71, 893-905DOI: (10.1086/342929) Copyright © 2002 The American Society of Human Genetics Terms and Conditions