Fig. 4. Features of PH in LLC1 lung tumor mice.

Slides:

Advertisements

Similar presentations

Respiration 2012;83:74–80 - DOI: /

Advertisements

Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway SuppressionCLINICAL PERSPECTIVE by Daile.

Fig. 2. LUM015 fluorescently labels tumor cells in mouse models of STS and breast cancer. LUM015 fluorescently labels tumor cells in mouse models of STS.

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

Fig. 1. FMRP deficiency leads to increased NSC activation in the adult dentate gyrus. FMRP deficiency leads to increased NSC activation in the adult dentate.

Fig. 3. Features of PH in KRasLA2 transgenic mice.

Fig. 4. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin expression. Intramuscular injection of AAV9-Cas9/sgRNA-51 corrects dystrophin.

In vivo function of MeTro sealants using rat incision model of lungs

Fig. 7. Role of PDE5 up-regulation in lung cancer–associated PH.

Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent manner. Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent.

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

Fig. 5 Maraba induces antitumor T cell immunity.

Fig. 6. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex vivo. Combinatorial VCPI and OV M1 treatment is efficacious in vivo and ex.

Fig. 5. Prophylactic treatment with GS-5734 reduces SARS-CoV disease.

Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells.

Fig. 8. In vivo suppression of MM by CMLD

Fig. 1. NASH and fibrosis develop late in mice fed an HFD.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Fig. 4. Characterization of human liver seed graft morphology.

Intravenous delivery of reovirus to primary and secondary brain tumors

Fig. 2. GPC3 expression in normal and tumor tissues.

Fig. 1. Paclitaxel delays tumor growth and promotes infiltration of TIE2hi/VEGFhi macrophages and TMEM assembly. Paclitaxel delays tumor growth and promotes.

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

Fig. 5. Pharmacological JAK2 inhibition in vivo abrogates tumor-initiating potential after chemotherapy. Pharmacological JAK2 inhibition in vivo abrogates.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Fig. 1. IS mediates a hyperthrombotic uremic phenotype in an AHR-dependent manner across CKD stages. IS mediates a hyperthrombotic uremic phenotype in.

Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.

Fig. 2 In vitro assessment of hESC-RPE cell sheets.

Fig. 2 STED microscopy of isolated cardiomyocytes from mice treated with MP-rhodamine–loaded CaPs. STED microscopy of isolated cardiomyocytes from mice.

Fig. 6 pDCs infiltrate the skin of BLM-treated mice, and their depletion attenuates skin fibrosis. pDCs infiltrate the skin of BLM-treated mice, and their.

Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

Fig. 4. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in vivo. BET inhibition sensitizes HR-proficient tumors to PARPi treatment in.

Fig. 5. Accelerated NASH-driven fibrogenesis in obese IFN-γ−/− mice is characterized by severe eosinophilic inflammation during TGF-β blockade. Accelerated.

Role of immune and inflammatory cells in lung cancer–associated PH

Fig. 7. NPs accumulate at sites of vascular obstruction.

Fig. 5 Local gel scaffold for T cell memory response.

Fig. 4. Irisin protected against oxidative stress and apoptosis in IR-injured lung tissue. Irisin protected against oxidative stress and apoptosis in IR-injured.

Fig. 2 Fas controls IL-1RA–sEV secretion in murine MSCs.

Fig. 4. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model of ALS. Loss of DLK expression is neuroprotective in the SOD1G93A mouse model.

Elysse C. Filipe et al. BTS 2018;3:38-53

Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.

Fig. 5. Nutlin-3 treatment rescues the proliferation and differentiation of NPCs in vitro. Nutlin-3 treatment rescues the proliferation and differentiation.

Stroke induces atheroprogression via the RAGE-signaling pathway

Fig. 4 TNF-α up-regulates Fas/Fap-1 expression to promote IL-1RA–sEV release in murine MSCs. TNF-α up-regulates Fas/Fap-1 expression to promote IL-1RA–sEV.

Fig. 6. pKL cells revert hyperglycemia in NOD mice in vivo.

Fig. 7. Genetic ablation of UCP2 compromised the protective effect of exogenous irisin on lung IR injury. Genetic ablation of UCP2 compromised the protective.

Fig. 3. VEGFR-3 signaling increases infiltration of naïve T cells in a CCR7-dependent manner. VEGFR-3 signaling increases infiltration of naïve T cells.

Fig. 1 Collecting popliteal lymphatic vessels exhibit diminished contraction and lymph velocity after MRSA infection. Collecting popliteal lymphatic vessels.

Fig. 4. Acute lung injury in miR-223−/y mice.

Fig. 3 CSF1 is expressed in human melanoma.

Fig. 7 Analysis of the bacterial nidus within tissue abscesses by MALDI IMS demonstrates a paucity of calprotectin signal. Analysis of the bacterial nidus.

Fig. 6 Photoreceptor cell survival in the RCS rat retina after transplantation with hESC-RPE cell sheets. Photoreceptor cell survival in the RCS rat retina.

Correlation of reovirus RNA/protein with proliferating tumor cells

Fig. 1 Neutrophils derived from patients with MPNs are associated with an increase in NET formation and a prothrombotic, NET-rich phenotype. Neutrophils.

Fig. 6 Combination therapy with LVSOD2 and LVshCTGF preserves flap volume and reduces fibrosis after RT. Combination therapy with LVSOD2 and LVshCTGF preserves.

Fig. 7 Transient immunosuppression (4 weeks) supports long-term graft survival and is associated with progressive decrease in spinal regional inflammatory.

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Fig. 3. Features of PH in KRasLA2 transgenic mice.

Colonization in tumor models and different modes of administration

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Fig. 1 Neu1−/− fibroblasts have characteristics of myofibroblasts.

Fig. 2. LUM015 fluorescently labels tumor cells in mouse models of STS and breast cancer. LUM015 fluorescently labels tumor cells in mouse models of STS.

Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models by Pauline Désogère, Luis F. Tapias, Lida P. Hariri,

Fig. 1. Matrix stiffness sensitizes myofibroblasts to apoptosis induced by inhibition of their mechanotransduction pathways. Matrix stiffness sensitizes.

Fig. 5. Vascularization of human liver seed grafts.

Fig. 6 Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9 in vivo. Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9.

In vivo effects of TTFields on intradermal tumors in mice.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Presentation transcript:

Fig. 4. Features of PH in LLC1 lung tumor mice. Features of PH in LLC1 lung tumor mice. (A) Schematic of the experimental design. C57BL/6 mice were intravenously injected with saline (WT) or LLC1 cells. After 10, 14, and 18 days from the initial injection, WT and LLC1 lung tumor–bearing mice underwent echocardiographic and physiological measurements. (B) Representative hematoxylin and eosin–stained sections of mouse lungs. Scale bar, 500 μm. (C) Echocardiographic measurements. (D) Physiological measurements of RVSP, SAP, PO2, and PVR of the mice. For WT, n = 9; for LLC1, n = 10. (E) Representative photomicrographs of vWF (brown)–stained and α-SMA (violet)–stained tissues, followed by (F) quantification of pulmonary vascular muscularization (given as a percentage for each range of vessel sizes). Scale bars, 20 μm. (G) Representative photomicrographs of elastica van Gieson–stained tissues, followed by (H) quantification of medial wall thickness of pulmonary vessels. Scale bars, 20 μm. (I) Representative photomicrographs of Sirius red staining (right). Scale bars, 20 μm. Quantitative image analysis of Sirius red staining (collagen deposition) in RV (left). For WT, n = 9; for LLC1, n = 10. *P < 0.05, ***P < 0.001 compared with WT; §P < 0.05, §§P < 0.01, §§§P < 0.001 compared with nontumor tissue of LLC1. Soni Savai Pullamsetti et al., Sci Transl Med 2017;9:eaai9048 Published by AAAS