Health-Related Quality of Life in Patients Attending a Gastroenterology Outpatient Clinic: Functional Disorders Versus Organic Diseases Magnus Simrén,

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Health-Related Quality of Life in Patients Attending a Gastroenterology Outpatient Clinic: Functional Disorders Versus Organic Diseases Magnus Simrén, Jan Svedlund, Iris Posserud, Einar S. Björnsson, Hasse Abrahamsson Clinical Gastroenterology and Hepatology Volume 4, Issue 2, Pages 187-195 (February 2006) DOI: 10.1016/S1542-3565(05)00981-X Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 Mean scores on the different SF-36 domains in patients with functional GI disorders and organic GI diseases. For comparison, normal values from the Swedish population are displayed,32 although no formal statistical comparisons between the patients’ groups and these values were performed. Patients with functional GI disorders had significant reductions in all domains of SF-36 as compared with patients with organic GI diseases, except for physical functioning and role emotional. *P < .05, **P < .01, ***P < .001 functional vs organic group. PF, Physical Functioning; RP, Role Physical; BP, Bodily Pain; GH, General Health; VT, Vitality; SF, Social Functioning; RE, Role Emotional; MH, Mental Health. Clinical Gastroenterology and Hepatology 2006 4, 187-195DOI: (10.1016/S1542-3565(05)00981-X) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 2 Mean item scores on the different PGWB domains in patients with functional GI disorders and organic GI diseases. For comparison, normal values from the Swedish population are displayed,27 although no formal statistical comparisons between the patients’ groups and these values were performed. Patients with functional GI disorders had significant reductions in all domains as compared with patients with organic GI diseases. *P < .05, **P < .01, ***P < .001 functional vs organic group. Anx, Anxiety; Depr, Depression; Pwb, Psychological Well-Being; Sc, Self control; Gh, General health; Vit, Vitality. Clinical Gastroenterology and Hepatology 2006 4, 187-195DOI: (10.1016/S1542-3565(05)00981-X) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 3 Mean item scores on the different domains on GSRS in patients with functional GI disorders and organic GI diseases. For comparison, normal values from the Swedish population are displayed,27 although no formal statistical comparisons between the patients’ groups and these values were performed. Patients with functional GI disorders had more severe reflux, abdominal pain, constipation, and indigestion than patients with organic GI diseases as assessed by GSRS, and only for diarrhea was the perceived severity similar in the 2 patient groups. *P < .05, **P < .01, ***P < .001 functional vs organic group. Clinical Gastroenterology and Hepatology 2006 4, 187-195DOI: (10.1016/S1542-3565(05)00981-X) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 4 Mean scores on the different SF-36 domains in patients with different perceived severity of GI symptoms based on the total scores on the GSRS. Patients with mild symptom severity do not seem to differ from the general population, but with increasing severity of GI symptoms, there is a gradual reduction in HRQOL as measured by SF-36 (P < .0001 for all comparisons). Clinical Gastroenterology and Hepatology 2006 4, 187-195DOI: (10.1016/S1542-3565(05)00981-X) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 5 Mean item scores on the different PGWB domains in patients with different perceived severity of GI symptoms based on the total scores on the GSRS. Patients with mild symptom severity do not seem to differ from the general population, but with increasing severity of GI symptoms, there is a gradual reduction in HRQOL as measured by PGWB (P < .0001 for all comparisons). Clinical Gastroenterology and Hepatology 2006 4, 187-195DOI: (10.1016/S1542-3565(05)00981-X) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions