Midkine and Melanoma Metastasis: A Malevolent Mix

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Presentation transcript:

Midkine and Melanoma Metastasis: A Malevolent Mix Sinem Karaman, Kari Alitalo Developmental Cell Volume 42, Issue 3, Pages 205-207 (August 2017) DOI: 10.1016/j.devcel.2017.07.015 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Midkine Expression by Melanomas Promotes Lymphovascular Niche Formation and Tumor Metastasis Olmeda et al. (2017) show that midkine (MDK) expression increases during the progression of human melanomas. In a subset of human melanomas, MDK is produced at high levels, and in mice, tumor xenografts of these cancers stimulate systemic lymphangiogenesis and tumor cell transmigration through the lymphatic endothelium in pre-metastatic sites, such as the draining lymph nodes. MDK binds heparan sulfate and lymphatic endothelial cells (LECs), in which it activates mTOR signaling to increase the expression of VEGFR3, through which major lymphangiogenic signals are transduced. Developmental Cell 2017 42, 205-207DOI: (10.1016/j.devcel.2017.07.015) Copyright © 2017 Elsevier Inc. Terms and Conditions