Daniela P. Metz, PhDa, Annette S

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Presentation transcript:

Phenotypic characterization of T cells infiltrating the conjunctiva in chronic allergic eye disease Daniela P. Metz, PhDa, Annette S. Bacon, FRCOphthb, Stephen Holgate, MD, DSC, FRCPc, Susan L. Lightman, PhDb,d Journal of Allergy and Clinical Immunology Volume 98, Issue 3, Pages 686-696 (September 1996) DOI: 10.1016/S0091-6749(96)70103-3 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Expression of T-cell subsets in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Expression of T-cell subsets in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Expression of T-cell subsets in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with VKC (B) stained with anti-CD3. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with VKC (B) stained with anti-CD3. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Expression of different CD45 isoforms in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Expression of different CD45 isoforms in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Expression of different CD45 isoforms in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Serial tissue sections from tarsal conjunctiva of patient with VKC showing: A, CD45RO+ cells in epithelium and subepithelium; and B, CD45RA+ cells in the same microscopic field as in A. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Serial tissue sections from tarsal conjunctiva of patient with VKC showing: A, CD45RO+ cells in epithelium and subepithelium; and B, CD45RA+ cells in the same microscopic field as in A. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Expression of HLA-DR, CD68, and CD1A in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Expression of HLA-DR, CD68, and CD1A in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Expression of HLA-DR, CD68, and CD1A in allergic and normal conjunctiva. Cell counts are expressed as means ± SEM. Comparisons between chronic allergic and normal conjunctiva were analyzed by using the Mann-Whitney U test. SE, Subepithelium; T, tarsal; B, bulbar. *p ≤ 0.05, **p ≤ 0.01. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 6 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with GPC (B) stained with anti-HLA-DR. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 6 Tarsal tissue section from normal conjunctiva (A) and conjunctiva of patient with GPC (B) stained with anti-HLA-DR. E, Epithelium; SE, subepithelium. Journal of Allergy and Clinical Immunology 1996 98, 686-696DOI: (10.1016/S0091-6749(96)70103-3) Copyright © 1996 Mosby, Inc. Terms and Conditions