Reduced percentage of natural killer cells associated with impaired cytokine network in the secretory endometrium of infertile women with polycystic ovary.

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Presentation transcript:

Reduced percentage of natural killer cells associated with impaired cytokine network in the secretory endometrium of infertile women with polycystic ovary syndrome Maria Matteo, M.D., Ph.D., Gaetano Serviddio, M.D., Francesca Massenzio, Ph.D., Giuseppina Scillitani, M.D., Laura Castellana, Ph.D., Giuseppe Picca, M.D., Francesca Sanguedolce, M.D., Mauro Cignarelli, M.D., Emanuele Altomare, M.D., Pantaleo Bufo, M.D., Pantaleo Greco, M.D., Arcangelo Liso, M.D., Ph.D. Fertility and Sterility Volume 94, Issue 6, Pages 2222-2227.e3 (November 2010) DOI: 10.1016/j.fertnstert.2010.01.049 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Expression of IL-15, IL-18, and CXCL10 mRNA levels isolated from the endometrium of patients with PCOS and healthy women was measured using real-time RT-PCR. Data are expressed as mean ± SD. Beta-actin mRNA expression arbitrarily assumed the value of 1 and was used to normalize the mRNA expression of each sample; P values refer to unpaired t-test analysis. Fertility and Sterility 2010 94, 2222-2227.e3DOI: (10.1016/j.fertnstert.2010.01.049) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Representative single-color histogram of CD56 cells. Fertility and Sterility 2010 94, 2222-2227.e3DOI: (10.1016/j.fertnstert.2010.01.049) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Representative graph showing control Ig-labeled cells. Fertility and Sterility 2010 94, 2222-2227.e3DOI: (10.1016/j.fertnstert.2010.01.049) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Immunohistochemical expression of IL-15, IL-18, and CXCL10 (from top to bottom) in selected cases of PCOS (A, C, E) as compared with controls (B, D, F). Fertility and Sterility 2010 94, 2222-2227.e3DOI: (10.1016/j.fertnstert.2010.01.049) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions