Tissue concentrations of endothelins and functional effects of endothelin-receptor activation in human arteries and veins Peter Holm, MD, Anders Franco-Cereceda,

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Presentation transcript:

Tissue concentrations of endothelins and functional effects of endothelin-receptor activation in human arteries and veins Peter Holm, MD, Anders Franco-Cereceda, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 2, Pages 264-272 (August 1996) DOI: 10.1016/S0022-5223(96)70248-9 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black squares). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black squares). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black squares). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black squares). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Contractile effects of ET-1 in human LADs, PAs, ITAs, and SVs in control experiments (open squares) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Contractile effects of ET-1 in human LADs and PAs in control experiments (open squares) and after incubation with bosentan at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Contractile effects of ET-1 in human LADs and PAs in control experiments (open squares) and after incubation with bosentan at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black circles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black circles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black circles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with indomethacin 10-5 mol/L and l-NMMA 10-4 mol/L (black circles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Contractile effects of ET-3 in human LADs, PAs, ITAs, and SVs in control experiments (open circles) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 Contractile effects of sarafotoxin 6c on LADs in control experiments (open triangles) and after incubation with BQ-123 at 10-6 mol/L (black circles) or 10-5 mol/L (black triangles). Data are presented as means ± standard error of the mean and are expressed as percentage of the maximal contraction induced by a 127 mmol/L concentration of K+. *p < 0.05, **p < 0.01, Mann-Whitney U test, compared with control experiments. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 264-272DOI: (10.1016/S0022-5223(96)70248-9) Copyright © 1996 Mosby, Inc. Terms and Conditions