X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

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Presentation transcript:

In vivo T1ρ and T2 mapping of articular cartilage in osteoarthritis of the knee using 3T MRI X. Li, Ph.D., C. Benjamin Ma, M.D., T.M. Link, M.D., D.-D. Castillo, B.S., G. Blumenkrantz, B.S., J. Lozano, B.S., J. Carballido-Gamio, Ph.D., M. Ries, M.D., S. Majumdar, Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 7, Pages 789-797 (July 2007) DOI: 10.1016/j.joca.2007.01.011 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 T1-weighted water excitation SPGR image (a), T1ρ map (b) and T2 map (c) for a healthy control (male, 30). No radiographs were obtained, as the subject is a healthy asymptomatic control. No cartilage thinning, osteophytes and other OA symptoms were seen in MR images. The average T1ρ value was 40.1±11.4ms and the average T2 value was 33.3±10.5ms in cartilage. Osteoarthritis and Cartilage 2007 15, 789-797DOI: (10.1016/j.joca.2007.01.011) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Radiographs (a), T1-weighted water excitation SPGR image (b), T1ρ map (c) and T2 map (d) for a patient with mild OA (male, 66). From radiographs, no significant joint space narrowing was seen, but minimal osteophytes were observed in femoro-tibial joint and minimal to mild osteophytes were observed in femoro-patellar joint, resulting in a KL score of 1. From MR images, minimal osteophytes were also seen in femoro-tibial and femoro-patellar joints. The cartilage in medial femur and femoro-patellar compartment had grade 1 thinning. The average T1ρ value was 45.5±14.5ms and the average T2 value was 35.0±10.9ms in cartilage. Osteoarthritis and Cartilage 2007 15, 789-797DOI: (10.1016/j.joca.2007.01.011) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Radiographs (a), T1-weighted water excitation SPGR image (b), T1ρ map (c) and T2 map (d) for a patient with advanced OA (male, 46). Based on radiographs, the patient had joint space narrowing with 1mm in medial compartment and 3mm in lateral compartment, and significant osteophytes in both femoro-tibial and femoro-patellar joints, resulting in a KL score of 4. In MR images, significant osteophytes were seen in both femoro-tibial and femoro-patellar joints. The cartilage had a grade 3 thinning in medial femur, medial tibia and femoro-patellar compartments, and grade 2 thinning in lateral femur and LT compartments. The average T1ρ value was 55.4±26.0ms and the average T2 value was 43.8±11.1ms in cartilage. Osteoarthritis and Cartilage 2007 15, 789-797DOI: (10.1016/j.joca.2007.01.011) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Distribution of T1ρ values vs age in healthy volunteers. The correlation is moderate but significant with R2=58.3% and P=0.018. Osteoarthritis and Cartilage 2007 15, 789-797DOI: (10.1016/j.joca.2007.01.011) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Segmented femoral and tibial cartilage in medial compartments of a healthy control (a, male, 30) and an OA patient (b, male, 66). The average thickness (in mm) is 1.68 vs 1.84 (control vs OA) in MFC, and 1.63 vs 1.71 (control vs OA) in MT. The volume (normalized by epicondylar length, in cm3/cm) is 0.31 vs 0.35 (control vs OA) in MFC, and 0.20 vs 0.19 (control vs OA) in MT. The slightly increased cartilage volume and thickness may due to the increase of water content and consequently swelling of the cartilage in the early stages of OA. Osteoarthritis and Cartilage 2007 15, 789-797DOI: (10.1016/j.joca.2007.01.011) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions