Vitamin D levels and patient outcome in chronic kidney disease

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Date of download: 7/3/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Fibroblast Growth Factor 23 and Risks of Mortality.

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Presentation transcript:

Vitamin D levels and patient outcome in chronic kidney disease Pietro Ravani, Fabio Malberti, Giovanni Tripepi, Paola Pecchini, Sebastiano Cutrupi, Patrizia Pizzini, Francesca Mallamaci, Carmine Zoccali Kidney International Volume 75, Issue 1, Pages 88-95 (January 2009) DOI: 10.1038/ki.2008.501 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Distribution of 25-hydroxy-vitamin D (25D, gray) and 1,25-di-hydroxy-vitamin D (1,25D, white) by tertile of glomerular filtration rate at baseline. Kidney International 2009 75, 88-95DOI: (10.1038/ki.2008.501) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 2 Relationships among 1,25-di-hydroxy-vitamin D (1,25D), 25-hydroxy-vitamin D (25D) and parathyroid hormone (PTH). PTH and 25D had positively skewed distributions and were log transformed (see values in parentheses). The corresponding untransformed values are also given. Kidney International 2009 75, 88-95DOI: (10.1038/ki.2008.501) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 3 Crude renal and patient survival curves by presence of 25D deficiency (levels of 25D <15 vs 15 ng/ml or greater). Kidney International 2009 75, 88-95DOI: (10.1038/ki.2008.501) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 4 Hazard ratios (HRs) and 95% confidence intervals (95% CI) for dialysis and death associated with the covariates in the final competing risk model (Table 3). The model is stratified by event type and eGFR tertile (<20, 20–40, >40 ml/min). The specific effect of each covariate on each study outcome is reported in the figure. Baseline levels of 25-hydroxy-vitamin D (10 ng/ml increase), time-varying use of converting enzyme inhibitors or angiotensin receptors blockers (CEI/ARB), and time-varying values of phosphate affected both risks (dialysis and death); time-varying daily proteinuria values (1–2 g vs <1 and >2 vs <1 g/day) had a dialysis-specific effect; age, smoking habit, history of heart failure, and time-varying values of C-reactive protein (mg/l) and serum albumin (<4 vs ≥4 g/100 ml) had a specific effect on patient mortality. Kidney International 2009 75, 88-95DOI: (10.1038/ki.2008.501) Copyright © 2009 International Society of Nephrology Terms and Conditions