Increased IL-33 expression by epithelial cells in bronchial asthma

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Presentation transcript:

Increased IL-33 expression by epithelial cells in bronchial asthma David Préfontaine, MSc, Jessica Nadigel, BSc, Fazila Chouiali, MSc, Séverine Audusseau, MSc, Abdelhabib Semlali, PhD, Jamila Chakir, PhD, James G. Martin, MD, DSc, Qutayba Hamid, MD, PhD Journal of Allergy and Clinical Immunology Volume 125, Issue 3, Pages 752-754 (March 2010) DOI: 10.1016/j.jaci.2009.12.935 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Epithelial IL-33 immunoreactivity in bronchial asthma compared with controls. Endobronchial tissue sections from subjects with mild asthma (A), subjects with severe asthma (B), and controls (C) were stained by immunocytochemistry. Preabsorption of primary antibody with recombinant IL-33 abolished staining on a severe asthma section (D). E, IL-33 staining intensity was blindly graded and revealed an increased immunoreactivity in subjects with severe asthma versus control subjects. Mod., Moderate. Journal of Allergy and Clinical Immunology 2010 125, 752-754DOI: (10.1016/j.jaci.2009.12.935) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Cultured bronchial epithelial cells isolated from subjects with asthma exhibit elevated baseline IL-33/glyceraldehyde-3-phosphate (GAPDH) mRNA ratios versus cells from subjects without asthma (P < .05). B, Elevated IL-33 cytokine levels were detected in BALF from adults with moderate asthma compared with those from controls with mild asthma or without asthma (n = 10 per group; P < .05; Bonferroni test). ELISA experiments were run in duplicate. Journal of Allergy and Clinical Immunology 2010 125, 752-754DOI: (10.1016/j.jaci.2009.12.935) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions