Volume 383, Issue 9921, Pages (March 2014)

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Volume 383, Issue 9921, Pages 970-983 (March 2014) Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants The Lancet Volume 383, Issue 9921, Pages 970-983 (March 2014) DOI: 10.1016/S0140-6736(13)61836-X Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Hazard ratios per 5 kg/m2 higher body-mass index adjusted for different combinations of mediators in coronary heart disease and stroke All hazard ratios were also adjusted for confounders as described in Methods. The appendix (pp 19–36) shows cohort-specific hazard ratios. The Lancet 2014 383, 970-983DOI: (10.1016/S0140-6736(13)61836-X) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Stratified analyses of HRs per 5 kg/m2 higher body-mass index, with and without adjustment for mediators in CHD (A) and stroke (B) p values were meta-regression p values between groups. Results are presented for all three mediators combined. The appendix (pp 73–90) shows HRs with adjustment for combinations of one and two mediators. CHD=coronary heart disease. HR=hazard ratio The Lancet 2014 383, 970-983DOI: (10.1016/S0140-6736(13)61836-X) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Percentage of excess risk per 5 kg/m2 higher body-mass index mediated through different combinations of metabolic risk factors in coronary heart disease and stroke The Lancet 2014 383, 970-983DOI: (10.1016/S0140-6736(13)61836-X) Copyright © 2014 Elsevier Ltd Terms and Conditions