Epithelial Cell Division: Aurora Kicks Lgl to the Cytoplasmic Curb Yu-ichiro Nakajima, Matthew C. Gibson  Current Biology  Volume 25, Issue 1, Pages R43-R45 (January 2015) DOI: 10.1016/j.cub.2014.11.052 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Lgl relocalization is triggered by AurA-mediated phosphorylation at the onset of mitosis and its redistribution is necessary for planar spindle orientation in epithelia. (A) During interphase, Lgl is restricted from the apical cortex by aPKC-mediated phosphorylation. (B) Upon prophase entry, AurA directly phosphorylates specific serine residues (S656, S664), releasing Lgl from the basolateral cortex into the cytoplasm. (C) Lgl relocalization is hypothesized to allow mitotic spindles to align at the basolateral region, where Dlg and the Pins complex may interact. Grey, Adherens junctions; green, basolateral cortex. Current Biology 2015 25, R43-R45DOI: (10.1016/j.cub.2014.11.052) Copyright © 2015 Elsevier Ltd Terms and Conditions