Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT T. Lowitz, O.

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Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT T. Lowitz, O. Museyko, V. Bousson, L. Laouisset, W.A. Kalender, J.-D. Laredo, K. Engelke Osteoarthritis and Cartilage Volume 21, Issue 7, Pages 957-964 (July 2013) DOI: 10.1016/j.joca.2013.04.006 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 (a) MR image with segmented BML and neighborhood VOI, (b) VOIs registered rigidly to CT image of the same knee, (c) color maps of MR signal intensity distribution vs BMD distribution in three BMLs (red corresponds to high signal intensity, blue to low signal intensity). The pair of color maps on the left corresponds to the BML shown in (a) and (b). Osteoarthritis and Cartilage 2013 21, 957-964DOI: (10.1016/j.joca.2013.04.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 (a) Neighborhood VOI four times the size of the BML VOI, (b) neighborhood VOI generated with a constant dilation from the BML VOI. Shown are the contour lines of the VOIs. Osteoarthritis and Cartilage 2013 21, 957-964DOI: (10.1016/j.joca.2013.04.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 (a) VOIs in CT image of BML group [compare Fig. 1(b)], (b) VOIs registered elastically to CT image of control knee (different shape) (BMD was calculated as the mean from five different randomly assigned control knees). Osteoarthritis and Cartilage 2013 21, 957-964DOI: (10.1016/j.joca.2013.04.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 CT image with analysis VOIs. Osteoarthritis and Cartilage 2013 21, 957-964DOI: (10.1016/j.joca.2013.04.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 CT-MR rigid registration. (a) Original, (b) and (c) manually translated and rotated to score MMI values. Osteoarthritis and Cartilage 2013 21, 957-964DOI: (10.1016/j.joca.2013.04.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions