Volume 18, Issue 2, Pages 143-149 (April 2011) Different responses of nitric oxide synthase inhibition on morphine-induced antinociception in male and female rats  Mahmoud Hosseini, Zahra Taiarani, Mosa Al-Reza Hadjzadeh, Soodabeh Salehabadi, Maryam Tehranipour, Hojjat Allah Alaei  Pathophysiology  Volume 18, Issue 2, Pages 143-149 (April 2011) DOI: 10.1016/j.pathophys.2010.05.004 Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Comparison of basal reaction times between female and male controls, female-LN and male-LN rat groups. Data are presented as means±SEM (n=10 in each group). Pathophysiology 2011 18, 143-149DOI: (10.1016/j.pathophys.2010.05.004) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Comparison of reaction times after injection of morphine (10mg/kg) between male and female controls. Data are presented as means±SEM (n=10 in each group). 15 and 30min after injection of morphine the reaction times in male group were higher than female group. **p<0.01 compared to female group. Pathophysiology 2011 18, 143-149DOI: (10.1016/j.pathophys.2010.05.004) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Comparison of reaction times after injection of morphine (10mg/kg) between female controls and female-LN group. Data are presented as means±SEM (n=10 in each group). Repeated measure ANOVA showed that the reaction times in female-LN group was higher than female controls. The animals of female-LN group were treated by l-NAME (10mg/kg/day) during 3 weeks. Pathophysiology 2011 18, 143-149DOI: (10.1016/j.pathophys.2010.05.004) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Comparison of reaction times after injection of morphine (10mg/kg) between male and male-LN groups. Data are presented as means±SEM (n=10 in each group). There was no significant difference between groups. The animals of male-LN group were treated by l-NAME (10mg/kg/day) during 3 weeks. Pathophysiology 2011 18, 143-149DOI: (10.1016/j.pathophys.2010.05.004) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Comparison of reaction times after injection of morphine (10mg/kg) between male-LN and female-LN groups. Data are presented as means±SEM (n=10 in each group). 45min after injection of morphine, the reaction time in female-LN group was significantly higher male-LN group. The animals of both groups were treated by l-NAME (10mg/kg/day) during 3 weeks. ***p<0.001 compared to male-LN group. Pathophysiology 2011 18, 143-149DOI: (10.1016/j.pathophys.2010.05.004) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions