By immunohistochemistry, 50% of inflammatory myofibroblastic tumours show expression of ALK, which correlates with ALK gene rearrangement. By immunohistochemistry, 50% of inflammatory myofibroblastic tumours show expression of ALK, which correlates with ALK gene rearrangement. ALK expression is inflammatory myofibroblastic tumours is most common in paediatric and young adult patients. B C Gleason, and J L Hornick J Clin Pathol 2008;61:428-437 Copyright © by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.