Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis  Michael D. Parkins, R. Andres Floto  Journal of Cystic Fibrosis  Volume 14, Issue 3, Pages 293-304 (May 2015) DOI: 10.1016/j.jcf.2015.03.012 Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Prevalence data of key emerging pathogens as a function of reporting country. These data demonstrate variably increasing prevalence of key emerging organisms over time, although, this is often country dependent. Inclusion and reporting criteria vary depending on registry (hence some data point not included), and generally represent at least one culture per calendar year and do not distinguish chronic infection from transient. Data adapted where available from 2003, 2008 and 2012 Australian Cystic Fibrosis Patient Registry, Canadian Cystic Fibrosis Patient Data Registry Report, UK Cystic Fibrosis Trust Annual Data Report and Cystic Fibrosis Foundation Patient Registry Annual Data Report and [122]. Journal of Cystic Fibrosis 2015 14, 293-304DOI: (10.1016/j.jcf.2015.03.012) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 A framework for investigating novel CF pathogens. Importantly, an identified agent may have some but not all of these factors, and may have a role some, but not all of the time. Journal of Cystic Fibrosis 2015 14, 293-304DOI: (10.1016/j.jcf.2015.03.012) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions