Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up

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Presentation transcript:

Skin pentosidine in very early hip/knee osteoarthritis (CHECK) is not a strong independent predictor of radiographic progression over 5 years follow-up P.A.J.M. Vos, P.M.J. Welsing, J. deGroot, A.M. Huisman, J.C.M. Oostveen, M. Reijman, J. Damen, S.C. Mastbergen, F.P.J.G. Lafeber Osteoarthritis and Cartilage Volume 21, Issue 6, Pages 823-830 (June 2013) DOI: 10.1016/j.joca.2013.03.006 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Difference between progression and burden of radiographic OA for participants with low and high skin pentosidine, uCTXII or the combination. Participants with low (white) and high (dashed) tertiles skin pentosidine (A–C; n = 66 in the low and high group), urine CTXII (D–F; n = 68 and 67 in the low and high group respectively), and both (G–I; n = 21 and 17 in the low and high group, respectively) at baseline. Differences in sum K&L (A, D, G), sum Altman JSN (B, E, H), and sum Altman osteophytes (C, F, I) scores are given. Median (dash), with the interquartile range (box; 50%) with the fifth and ninety-fifth percentiles (whiskers) are presented. P values are indicated. Osteoarthritis and Cartilage 2013 21, 823-830DOI: (10.1016/j.joca.2013.03.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Correlations skin pentosidine and uCTXII with parameters of radiographic progression and burden. For skin pentosidine the sum K&L scores for progression and burden (A and B, respectively) and for uCTXII the sum Altman JSN scores (C and D, respectively) are given as representative figures. Correlation coefficients with P values for all relations are given in Table II. Pearson correlation coefficients with P values are provided. Osteoarthritis and Cartilage 2013 21, 823-830DOI: (10.1016/j.joca.2013.03.006) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions