原核生物DNA的修复机制 潘明 柯永培 罗霞

DNA DAMAGE DNA is constantly subjected to injuries inflicted by external agents such as UV light or cigarette smoke, by intracellular by-products of metabolism such as reactive oxygen species, or by spontaneous decay. DNA lesions interfere with replication and with transcription and if left in DNA can cause mutation, malfunction, and cell death. These deleterious effects are usually prevented by DNA repair mechanisms, which remove the damaged nucleotide and restore the original DNA sequence

DNA REPAIR MECHISM Mismatch repair MMR Nucleotide excission repair NER Global genomic repair GGR Transcription coupled repair TCR Base excission repair BER Recombinational repair Doublestrand break repair DBS SOS translesion replication error-free error-phone O6-methyl guonine-DNA methyltransferaes MGMT

谢谢！