Changes in the 24-h plasma cortisol rhythm in patients with cirrhosis Sara Montagnese, Benita Middleton, Ali R. Mani, Debra J. Skene, Marsha Y. Morgan  Journal of Hepatology  Volume 54, Issue 3, Pages 588-590 (March 2011) DOI: 10.1016/j.jhep.2010.08.015 Copyright © 2010 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Plasma free cortisol (PFC) 24-h concentration-time curves in healthy volunteers (grey squares) and patients with cirrhosis (black rhomboids). Healthy volunteers showed a morning PFC double peak (06.00 and 08.30 – grey bar) and patients with cirrhosis showed a delayed PFC peak (10.00 and 13.00 – black bar). Journal of Hepatology 2011 54, 588-590DOI: (10.1016/j.jhep.2010.08.015) Copyright © 2010 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Plasma free cortisol (PFC) 24-h concentration-time curves in patients with Child’s A cirrhosis (black circles) and patients with Child’s B/C cirrhosis (grey triangles). Patients with Child’s B/C cirrhosis showed a more prominent delay in the timing of the cortisol peak compared to their counterparts with Child’s A cirrhosis, although statistical significance was not reached. Journal of Hepatology 2011 54, 588-590DOI: (10.1016/j.jhep.2010.08.015) Copyright © 2010 European Association for the Study of the Liver Terms and Conditions