Impact of gender on the renal response to angiotensin II

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Impact of gender on the renal response to angiotensin II Judith A. Miller, Laurie A. Anacta, Daniel C. Cattran Kidney International Volume 55, Issue 1, Pages 278-285 (January 1999) DOI: 10.1046/j.1523-1755.1999.00260.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Change in the glomerular filtration rate (A; ∆GFR), renal plasma flow (B; ∆ERPF) and filtration fraction (C; ∆FF) in response to angiotensin (Ang) II infusion at 0.5 ng/kg/min (Inf 1), 1.5 ng/kg/min (Inf 2), 2.5 ng/kg/min (Inf 3), and at recovery in men (▪) and women (). *P < 0.05 vs. response in men. Kidney International 1999 55, 278-285DOI: (10.1046/j.1523-1755.1999.00260.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Change in the glomerular filtration rate (A; ∆GFR), renal plasma flow (B; ∆ERPF) and filtration fraction (C; ∆FF) in response to Ang II infusion at 0.5 ng/kg/min (Inf 1), 1.5 ng/kg/min (Inf 2), 2.5 ng/kg/min (Inf 3), and at recovery in women with plasma 17ß-estradiol concentrations>300 pmol/liter () and women with plasma 17ß-estradiol concentrations <100 pmol/liter (▪). *P < 0.05 vs. response in women with high plasma 17ß-estradiol concentrations. Kidney International 1999 55, 278-285DOI: (10.1046/j.1523-1755.1999.00260.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between 17ß-estradiol plasma concentrations and change in renal plasma flow (A; ∆ERPF; P= 0.03, r= 0.39), glomerular filtration rate (B; ∆GFR; P= 0.77, r= 0.05), and aldosterone (C; ∆Aldosterone; P= 0.008, r= 0.49), in response to angiotensin (Ang) II infusion (1.5 ng/kg/min). Kidney International 1999 55, 278-285DOI: (10.1046/j.1523-1755.1999.00260.x) Copyright © 1999 International Society of Nephrology Terms and Conditions