Volume 13, Pages (September 2017)

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Volume 13, Pages 92-105 (September 2017) Impaired wound healing after radiation therapy: A systematic review of pathogenesis and treatment Lia K. Jacobson, Maxwell B. Johnson, Raj D. Dedhia, Solmaz Niknam-Bienia, Alex K. Wong JPRAS Open Volume 13, Pages 92-105 (September 2017) DOI: 10.1016/j.jpra.2017.04.001 Copyright © 2017 The Author(s) Terms and Conditions

Figure 1 Chronic effects of radiation are associated with non-healing wounds. JPRAS Open 2017 13, 92-105DOI: (10.1016/j.jpra.2017.04.001) Copyright © 2017 The Author(s) Terms and Conditions

Figure 2 Late effects and ulceration after radiation. JPRAS Open 2017 13, 92-105DOI: (10.1016/j.jpra.2017.04.001) Copyright © 2017 The Author(s) Terms and Conditions

Figure 3 PRISMA-P flow diagram. JPRAS Open 2017 13, 92-105DOI: (10.1016/j.jpra.2017.04.001) Copyright © 2017 The Author(s) Terms and Conditions

Figure 4 Classic stages of wound repair. a) Inflammation b) proliferation c) remodeling. Image borrowed with permission from Gurtner, GC; Werner, S; Barrandon, Y; and Longaker, MT. Wound repair and regeneration. Nature 2008. 453; 314-21. JPRAS Open 2017 13, 92-105DOI: (10.1016/j.jpra.2017.04.001) Copyright © 2017 The Author(s) Terms and Conditions

Figure 5 Summary of key factors in pathogenesis of delayed wound healing following radiation therapy. JPRAS Open 2017 13, 92-105DOI: (10.1016/j.jpra.2017.04.001) Copyright © 2017 The Author(s) Terms and Conditions