Regulation of T Helper 17 Differentiation by Orphan Nuclear Receptors: It's Not Just RORγt Anymore  Mark S. Sundrud, Anjana Rao  Immunity  Volume 28, Issue 1, Pages 5-7 (January 2008) DOI: 10.1016/j.immuni.2007.12.006 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 RORα and RORγ May Act Redundantly or Cooperatively to Regulate Th17 Differentiation Possible mechanisms, not mututally exclusive, whereby RORα and RORγt could regulate Th17-associated gene expression. Two genes bearing distinct retinoid response-like elements (ROREs), RORE-A and RORE-B, are shown. RORα and RORγt could be functionally redundant, binding to the same ROR response elements (ROREs) (top), they could bind to ROREs as heterodimers (middle), or they could each individually recognize unique sets of ROREs (bottom). In reality, each RORα or RORγt target gene is likely to contain several ROREs in its promoter and distal regulatory regions, and some or all of these scenarios may apply. Immunity 2008 28, 5-7DOI: (10.1016/j.immuni.2007.12.006) Copyright © 2008 Elsevier Inc. Terms and Conditions