A reliable rabbit model for hyperkinetic pulmonary hypertension

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A reliable rabbit model for hyperkinetic pulmonary hypertension Wei Wang, MD, Ruifang Liu, MD, Guangqing Cao, MD, Fang Zhang, MD, Yiqian Zhang, MD, Zhongming Zhang, MD, Shuming Wu, MD The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 2, Pages 395-399 (August 2010) DOI: 10.1016/j.jtcvs.2009.04.071 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Illustration of surgical technique. Anastomosis between left carotid artery and pulmonary trunk. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 395-399DOI: (10.1016/j.jtcvs.2009.04.071) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Three months after operation, shunted artery was detectable by echocardiography. A, Colorful blood flow can be seen running through shunt vessel into pulmonary artery during entire cardiac cycle. B, Continuous waveform can be detected in shunt vessel with continuous-wave Doppler. Maximum velocity of shunt flow jet was 2.8 ± 4.4 m/s (average 3.23 ± 0.62 m/s), and average differential of flow pressure between aorta (AO) and pulmonary artery (PA) was 54 ± 6 mm Hg. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 395-399DOI: (10.1016/j.jtcvs.2009.04.071) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Pathologic changes in pulmonary artery 3 months after operation (hematoxylin and eosin stain, ×200). A, Sham operation group. B, In shunt group, thickness of arterial wall increased and lumen became narrowed. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 395-399DOI: (10.1016/j.jtcvs.2009.04.071) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions