The metabolic network of arachidonic acid in human PMN, EC and PLT

Slides:

Advertisements

Similar presentations

GFP‐Sed5p localization defect in sgt2Δ.

Advertisements

Platelets in Atherothrombosis

Abundance of proteins matching selected subcellular locations and functions in CaCo‐2 cells. Abundance of proteins matching selected subcellular locations.

Global comparison of MinSpan pathways with databases of human‐defined pathways The pairwise connection specificity index (CSI) was calculated for all pathway.

Simulation of oxygen and substrate demands for ammonia detoxification.

Bifurcation diagrams showing quasi‐steady‐state solutions and simulation of models. Bifurcation diagrams showing quasi‐steady‐state solutions and simulation.

Summary of clinical and metabolic characteristics.

Usage of l‐carnitine antimetabolites for the treatment of HCCl‐Carnitine and metabolites in the l‐carnitine biosynthetic pathway, as well as two essential.

Most promoters preserve their relative activity levels across conditions. Most promoters preserve their relative activity levels across conditions. (A)

CNA‐driven network of glioblastoma.

Analysis of in silico flux changes along the exponential growth phase: (A) In silico flux changes from 24 to 36 h, from 36 to 48 h, and from 48 to 60 h.

Illustration of the reactions and metabolites obtained from random sampling. Illustration of the reactions and metabolites obtained from random sampling.

Six categories of uses and number of studies for each use of the E

Activity flow of the mTOR signaling network.

Heatmaps of the gene mutation distributions in oncogene‐signaling blocks for six representative cancer types. Heatmaps of the gene mutation distributions.

Exo‐metabolomics profiling of major metabolites elucidated the metabolic capabilities of monospecies Exo‐metabolomics profiling of major metabolites elucidated.

Predicted and measured double‐ring formation.

Functional analysis of duplicate pair CIK1–VIK1 (A) Genetic interaction profile similarity. Functional analysis of duplicate pair CIK1–VIK1 (A) Genetic.

(C–F) Complete interaction networks (representing both baits and preys) for selected groups of baits. (C–F) Complete interaction networks (representing.

Structure of in‐frame deletions.

Comparative analysis of RNA and protein profiles.

Large‐scale image‐based CRISPR‐Cas9 gene perturbation profiling

Correlating protein to mRNA and proteins per mRNA ratios

Phenogenetic networks of genes linked to Alzheimer's and Parkinson's disease reveal concordant phenotypes Phenogenetic networks of genes linked to Alzheimer's.

Network derived from large‐scale fractionation predicts 48 protein complexes and communities Network derived from large‐scale fractionation predicts 48.

Protein–lipid map in yeast.

Schematic of the integration and results of the alveolar macrophage (iAB‐AMØ‐1410) and Mycobacterium tuberculosis (iNJ661) reconstructions. Schematic of.

Networks of ERK substrates.

Alignment time for Clustal Omega (red), MAFFT (blue), MUSCLE (green) and Kalign (purple) against the number of sequences of HomFam test sets. Alignment.

The limiting, degrading entity hypothesis

Feature‐based COG enrichment analysis

Volume 71, Issue 11, Pages (June 2007)

Effect of the loss of Kar4 on the induction of various promoters

Characterization of Factor 5 (oxidative stress response factor) in the CLL data Characterization of Factor 5 (oxidative stress response factor) in the.

Optimality principles in adaptive evolution.

Chemical inhibitors of microtubule function attenuate signal but do not affect pathway variability Chemical inhibitors of microtubule function attenuate.

Neurogenins induce a network of transcription factors that mediate iNGN neurogenesisA network of transcription factors involved in iNGN neurogenesis was.

Francis Crick's central dogma of biology revolves around the transcription of mRNA from DNA, the translation of proteins from mRNA, and the degradation.

Notch activation in Notch1 positive feedback knock‐out intestine organoids Notch activation in Notch1 positive feedback knock‐out intestine organoids Intestine.

Allele‐specific expression at single‐cell resolution

Two‐way unsupervised uncentered unnormalized hierarchical clustering using a Pearson's correlation of the phenotypic profiles of 4281 nonessential genes.

Transcriptomic and epigenetic changes associated with Factor 1 in the scMT data Transcriptomic and epigenetic changes associated with Factor 1 in the scMT.

Categorizing cell type‐specific auxin responses.

Resolving Lipids: Lipoxins Regulate Reverse Cholesterol Transport

DominoEffect R package

Simulation showing that the cell length variability of the entire population can mask abnormal cell length variability at a specific cell cycle period.

An integrated NHR network.

Subnetworks enriched for the hallmarks of cancer.

Stage‐dependent diurnal transcript changes.

Example transcript and protein patterns.

Reproducibility of DeathPro drug screens

When grown with biofuel, strains with beneficial pumps dominate the culture. When grown with biofuel, strains with beneficial pumps dominate the culture.

Maintenance metabolism alone cannot explain non‐division

Melting behavior of protein complexes

In vivo imaging of the wound bed at later time points (related to Fig 7)‏ In vivo imaging of the wound bed at later time points (related to Fig 7) A–CRepresentative.

Nedd4 proteins. Nedd4 proteins. (A) Schematic representation of rNedd4‐1, hNedd4‐1 and hNedd4‐2 (not to scale), with % amino‐acid identity between them.

Correlations between metabolic pathway abundances and environmental conditions deduced from the ocean samples in this study, at various levels of model.

Experimental validation of predicted endocytosis functions in human.

A typical current computational meta'omic pipeline to analyze and contrast microbial communities. A typical current computational meta'omic pipeline to.

Global and focused views of human interaction map.

Schematics for nutrient pulse systems

Integration of proteomic data into the model

Glucose pulses incorporate directly into the de novo biomass in non‐dividing cells Glucose pulses incorporate directly into the de novo biomass in non‐dividing.

Glutamine addiction and cancer invasiveness are positively correlated in ovarian cancer cells (OVCA) Gln deprivation effect on proliferation rate of a.

Many of the diseases associated with high coevolution scores share genetic components. Many of the diseases associated with high coevolution scores share.

Proteomic analysis of human transcription factors Disease correlation of 19 TFs and 4 well‐studied FOX family members, based on their GO annotations. Proteomic.

Metabolic differences in the small intestine AMetabolic genes as well as the associated reactions involved in the formation of glutathione (GSH) are presented.B,

Intestinal differentiation is coupled with global rewiring of gene expression Intestinal differentiation is coupled with global rewiring of gene expression.

DuMPLING oligonucleotide plasmid library design and production

Celecoxib shunts arachidonic acid from the COX-2 pathway to the 5-LOX pathway. Celecoxib shunts arachidonic acid from the COX-2 pathway to the 5-LOX pathway.

Presentation transcript:

The metabolic network of arachidonic acid in human PMN, EC and PLT The metabolic network of arachidonic acid in human PMN, EC and PLT. Two pathways are responsible for the production of inflammatory mediators: COX‐2 pathway and 5‐LOX pathway. The metabolic network of arachidonic acid in human PMN, EC and PLT. Two pathways are responsible for the production of inflammatory mediators: COX‐2 pathway and 5‐LOX pathway. LTB4 and PGE2 are major inflammatory mediators produced in the AAnetwork. PGI2 and TXA2 are vasoactive molecules, the abnormal production of which causes bleeding and cardiovascular disease. The separate AAnetworks in PMN, EC and PLT can be found in Supplementary Figure S1. Kun Yang et al. Mol Syst Biol 2008;4:228 © as stated in the article, figure or figure legend