MIS12/MIND Control at the Kinetochore

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MIS12/MIND Control at the Kinetochore Rene Ladurner, Aaron F. Straight Cell Volume 167, Issue 4, Pages 889-891 (November 2016) DOI: 10.1016/j.cell.2016.10.036 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Model of Kinetochore Assembly and Disassembly in Mitosis (A) Prior to the entry into mitosis, CENP-C binds to the CENP-A nucleosome at the centromere. The MIS12/MIND complex is blocked from recruitment to kinetochores due to the inhibitory interaction between its two head domains that prevents its binding to CENP-C. (B) Aurora B kinase activity promotes kinetochore assembly at the centromere by phosphorylating MIS12/MIND to disrupt the interaction between its two head domains and relieve the autoinhibition. Once MIS12/MIND is bound to CENP-C, MIS12/MIND recruits microtubule binding complexes to kinetochores. (C) As cells exit mitosis, phosphorylation of MIS12/MIND disrupts its interaction with microtubule binding factors, and dephosphorylation of the centromere-proximal head reinstates the MIS12/MIND autoinhibition, leading to disassembly of kinetochores. Cell 2016 167, 889-891DOI: (10.1016/j.cell.2016.10.036) Copyright © 2016 Elsevier Inc. Terms and Conditions