Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine

Slides:

Advertisements

Similar presentations

Asymmetric Suzuki–Miyaura Coupling in Water with a Chiral Palladium Catalyst Supported on an Amphiphilic Resin Yasuhiro Uozumi Angew. Chem. Int. Ed. 2009,

Advertisements

1 CATALYTIC ASYMMETRIC NOZAKI- HIYAMA-KISHI REACTION: ROLE OF ORGANOCHROMIUM COMPOUNDS AND NOVEL SALEN LIGANDS A RKAJYOTI C HAKRABARTY Prof. Uday Maitra’s.

High-Oxidation-State Palladium Catalysis 报告人：刘槟 2010 年 10 月 23 日.

Song jin July 10, 2010 Gong Group Meeting.

Welcome to Interactive Chalkboard

Generics And Collection Interface

82 Chapter Brake System Diagnosis, Service, and Repair.

Hematologic Malignancies in Children

Kingdom Protista Sometimes called the “Junk drawer”

Waves and Vibrations Chapter 5.

OMICS Journals are welcoming Submissions

Connecticut Real Estate Legal Review and Update

CopyrightThe McGraw-Hill Companies, Inc

Quantitative Phase Imaging of Cells and Tissues

IN THIS CHAPTER, YOU WILL LEARN:

Risk and Return & The Capital Asset Pricing Model (CAPM)

Macro Unit II: Measuring Economic Performance

Maury Project Ocean Acidification

Instructor: Shengyu Zhang

Towards a Theory of Data-Independent Memory Hard Functions

Ordinary differential equations

Chapter 8 Rotational Motion

Major developments in Rh-catalyzed asymmetric 1,4-addition of boron species to enone Group Seminar By Raphaël Beltran.

The Books of the Bible.

Information Retrieval from Relational Databases

Data Structures and Programming Techniques

Ghrelin Mathematical Modeling

Jeopardy! Vancouver Math Olympiad Competition #4: Spring Event Game #1

نظرية الماغنيتون النووية لتكميم الكتلة و توحيد القوى الاربعة

Rotation Created by Craig Smiley (Harrison HS, West Lafayette, IN)

The volatility surface a practitioner’s tools

Memory Address Space and Data Organization

Recursion notes Chapter 8.

CS 376: Computer Vision - lecture 19

Cristobal Young Stanford University.

CS 3700 Networks and Distributed Systems

湖南大学-信息科学与工程学院-计算机与科学系

CIS 519/419 Applied Machine Learning

Lecture 1: Optimal Pricing for Monopoly with Multiple Goods

COMP 175: Computer Graphics April 2nd, 2018

NumericNoExplosionAnswer.

Statistics Chi-Square

Program Analyses using Newton's Method

Poisson and Normal Distributions

Support Vector Machine (SVM)

Lambda Calculus.

Topic 2: Mechanics 2.1 – Motion

Homomorphic Secret Sharing Yuval Ishai Technion

Topic 5: Electricity and magnetism 5

Topic 5: Electricity and magnetism 5

• First practical method for asymmetric hydrocyantion of a 1,3-diene

B-Hydroxysalicylhydrazones: Chiral, non-racemic tridentate catalysts for asymmetric synthesis Shawn R. Hitchcock, Department of Chemistry, Illinois State.

CIS 519/419 Applied Machine Learning

How Shall I Name Thee? Let me count the ways...

Multifactor Analysis of Variance

Statistics Chi-Square

Induction and Recursion

Computer Architecture Lecture 11a: Memory Latency, Energy, and Power

Gauss and All That Jazz ???? Associate Lecturer PSB

The Process of Digestion

Chemistry, The Central Science, 10th edition

CPSC 231: Making Decisions In Python

Risk Management Lecture 7.

Heavy-ion Fusion and Fission Studies at JAEA

Huawei SX7 Campus Switches Configuration Quotation Guide (Overseas)

Joseph B. Sweeney, Julien Doulcet, Bimod Thapa iScience

Learning outcomes By the end of this session you should know about:

Presentation transcript:

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine Kevin R. Campos J. Am. Chem. Soc. 2006, 128, 3538-3539

2-Arylpyrrolidines Biologically active compounds as neuronal nicotinic acetylcholine receptor. Effective controllers in asymmetric synthesis.

Conclusions The enantioselective deprotonation/transmetalation/Negishi coupling was found to be quite general, affording a diverse array of 2-arylpyrrolidines in good yield and 96:4 er. This sequence offers a number of advantages over existing methods and represents the most convenient and practical synthesis of enantiomerically enriched 2-arylpyrrolidines and 2,5-diarylpyrrolidines.