Cardiomyocytes Replicate and their Numbers Increase in Young Hearts

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Cardiomyocytes Replicate and their Numbers Increase in Young Hearts Nawazish Naqvi, Reena Singh, Siiri E. Iismaa, Ming Li, John W. Calvert, David I.K. Martin, Richard P. Harvey, Robert M. Graham, Ahsan Husain Cell Volume 163, Issue 4, Pages 783-784 (November 2015) DOI: 10.1016/j.cell.2015.10.038 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Verifying CM Mitoses in P15 Mouse Cardiac Left Ventricle by an Independent Laboratory from Blinded Histological Heart Samples (A and B) Immunohistochemical identification of mitotic CMs (red staining, Aurora B-positive cells) in transverse cut tissue sections showing localization in the left ventricle (LV) of P15 mice (B), with no Aurora B-positive cells evident in the LV of the P10 heart (A). CMs are labeled with cardiac troponin T (cTNT) (green) and nuclei are labeled with DAPI (blue). Arrows show some Aurora B-positive CMs. Experimental procedures used for immunohistochemistry were essentially as described (Naqvi et al., 2014). The Aurora B antibody (Abcam, ab 2254), supplied as a 1-mg/ml solution, was used at a dilution of 1:50. Sections were prepared and antibodies provided by the Graham laboratory. Immunohistochemical staining was performed in a blinded manner by the Harvey laboratory. Cell 2015 163, 783-784DOI: (10.1016/j.cell.2015.10.038) Copyright © 2015 Elsevier Inc. Terms and Conditions