Ari Karason, Johann E. Gudjonsson, Ruchi Upmanyu, Arna A

Slides:



Advertisements
Similar presentations
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
Advertisements

Copyright © 2000 American Medical Association. All rights reserved.
Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism  Laura Almasy, James E. Hixson,
A Novel Linkage to Generalized Vitiligo on 4q13-q21 Identified in a Genomewide Linkage Analysis of Chinese Families  Jian-Jun Chen, Wei Huang, Jin-Ping.
Quantitative-Trait Loci Influencing Body-Mass Index Reside on Chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study 
Homozygosity Mapping in Families with Joubert Syndrome Identifies a Locus on Chromosome 9q34.3 and Evidence for Genetic Heterogeneity  Kathrin Saar, Lihadh.
A Genomewide Screen of 345 Families for Autism-Susceptibility Loci
A Second Locus for Familial Generalized Epilepsy with Febrile Seizures Plus Maps to Chromosome 2q21-q33  Stéphanie Baulac, Isabelle Gourfinkel-An, Fabienne.
Comparison of Microsatellites Versus Single-Nucleotide Polymorphisms in a Genome Linkage Screen for Prostate Cancer–Susceptibility Loci  Daniel J. Schaid,
D. E. Grice, K. A. Halmi, M. M. Fichter, M. Strober, D. B. Woodside, J
Genomewide Scan in German Families Reveals Evidence for a Novel Psoriasis- Susceptibility Locus on Chromosome 19p13  Young-Ae Lee, Franz Rüschendorf, Christine.
Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4  Katrina A.B. Goddard, John S. Witte, Brian K.
Genomewide Linkage Scan Identifies a Novel Susceptibility Locus for Restless Legs Syndrome on Chromosome 9p  Shenghan Chen, William G. Ondo, Shaoqi Rao,
A Major Susceptibility Locus Influencing Plasma Triglyceride Concentrations Is Located on Chromosome 15q in Mexican Americans  Ravindranath Duggirala,
Genomewide Linkage Scan for Myopia Susceptibility Loci among Ashkenazi Jewish Families Shows Evidence of Linkage on Chromosome 22q12  Dwight Stambolian,
Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs  Jian Huang, Yanming Jiang  The.
Evidence for Sex-Specific Risk Alleles in Autism Spectrum Disorder
An Autosomal Dominant Thrombocytopenia Gene Maps to Chromosomal Region 10p  Anna Savoia, Maria Del Vecchio, Antonio Totaro, Silverio Perrotta, Giovanni.
Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome.
Quantitative-Trait Loci Influencing Body-Mass Index Reside on Chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study 
A Whole-Genome Scan in 164 Dutch Sib Pairs with Attention-Deficit/Hyperactivity Disorder: Suggestive Evidence for Linkage on Chromosomes 7p and 15q  S.C.
Anxiety with Panic Disorder Linked to Chromosome 9q in Iceland
A Combined Linkage-Physical Map of the Human Genome
A. Vanita, Jai Rup Singh, Virinder K
The Novel Genetic Disorder Microhydranencephaly Maps to Chromosome 16p  
Neuregulin 1 and Susceptibility to Schizophrenia
Use of Closely Related Affected Individuals for the Genetic Study of Complex Diseases in Founder Populations  C. Bourgain, E. Génin, P. Holopainen, K.
The American Journal of Human Genetics 
Elizabeth Theusch, Analabha Basu, Jane Gitschier 
Genomewide Scan for Hand Osteoarthritis: A Novel Mutation in Matrilin-3  Stefán Einar Stefánsson, Helgi Jónsson, Thorvaldur Ingvarsson, Ileana Manolescu,
Highly Significant Linkage to the SLI1 Locus in an Expanded Sample of Individuals Affected by Specific Language Impairment    The American Journal of.
Reduction of Sample Heterogeneity through Use of Population Substructure: An Example from a Population of African American Families with Sarcoidosis 
Evidence for a Nonallelic Heterogeneity of Epidermodysplasia Verruciformis with Two Susceptibility Loci Mapped to Chromosome Regions 2p21–p24 and 17q25 
Kristina Allen-Brady, Peggy A. Norton, James M
Ari Karason, Johann E. Gudjonsson, Hjörtur H. Jónsson, Valdimar B
Chuanhui Dong, Wei-Dong Li, Frank Geller, Lei Lei, Ding Li, Olga Y
Familial Juvenile Hyperuricemic Nephropathy: Localization of the Gene on Chromosome 16p11.2—and Evidence for Genetic Heterogeneity  Blanka Stibůrková,
A Genomewide Search Finds Major Susceptibility Loci for Nicotine Dependence on Chromosome 10 in African Americans  Ming D. Li, Thomas J. Payne, Jennie.
Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4  Katrina A.B. Goddard, John S. Witte, Brian K.
A Whole-Genome Scan and Fine-Mapping Linkage Study of Auditory-Visual Synesthesia Reveals Evidence of Linkage to Chromosomes 2q24, 5q33, 6p12, and 12p12 
Attention Deficit Hyperactivity Disorder: Fine Mapping Supports Linkage to 5p13, 6q12, 16p13, and 17p11  Matthew N. Ogdie, Simon E. Fisher, May Yang,
Erratum The American Journal of Human Genetics
A Genomewide Linkage Scan for Quantitative-Trait Loci for Obesity Phenotypes  Hong-Wen Deng, Hongyi Deng, Yong-Jun Liu, Yao-Zhong Liu, Fu-Hua Xu, Hui Shen,
Michael P. Epstein, Xihong Lin, Michael Boehnke 
D. E. Grice, K. A. Halmi, M. M. Fichter, M. Strober, D. B. Woodside, J
Long Homozygous Chromosomal Segments in Reference Families from the Centre d'Étude du Polymorphisme Humain  Karl W. Broman, James L. Weber  The American.
Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early- Onset Chronic Obstructive Pulmonary Disease  Edwin K. Silverman, Lyle.
Genomewide Scan in Families with Schizophrenia from the Founder Population of Afrikaners Reveals Evidence for Linkage and Uniparental Disomy on Chromosome.
Evidence That the Penetrance of Mutations at the RP11 Locus Causing Dominant Retinitis Pigmentosa Is Influenced by a Gene Linked to the Homologous RP11.
Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26  Susan.
Bruno Bucheton, Laurent Abel, Sayda El-Safi, Musa M
Identifying Novel Genes for Atherosclerosis through Mouse-Human Comparative Genetics  Xiaosong Wang, Naoki Ishimori, Ron Korstanje, Jarod Rollins, Beverly.
Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications 
Mean C-to-U editing ratios for most editing sites map to a region on chromosome 6 at 122 Mb. (A) Genome scan of mean C-to-U editing for 70 editing sites.
A Second Recombination Hotspot Associated with SHOX Deletions
Genome Scan of Human Systemic Lupus Erythematosus by Regression Modeling: Evidence of Linkage and Epistasis at 4p   C. Gray-McGuire, K.L. Moser,
Psoriasis Genetics: The Way Forward
Genome Screen to Identify Susceptibility Genes for Parkinson Disease in a Sample without parkin Mutations  Nathan Pankratz, William C. Nichols, Sean K.
Linkage Analyses at the Chromosome 1 Loci 1q24-25 (HPC1), 1q42
Amalia Martinez-Mir, Jianjun Liu, Derek Gordon, Madeline S
A Gene for an Autosomal Dominant Scleroatrophic Syndrome Predisposing to Skin Cancer (Huriez Syndrome) Maps to Chromosome 4q23  Young-Ae Lee, Howard P.
Whole-Genome Scan, in a Complex Disease, Using 11,245 Single-Nucleotide Polymorphisms: Comparison with Microsatellites  Sally John, Neil Shephard, Guoying.
Simone Sanna-Cherchi, Gianluca Caridi, Patricia L
Endometriosis is not associated with or linked to the GALT gene
Kathleen A. Daly, W. Mark Brown, Fernando Segade, Donald W
Homozygosity Mapping in Families with Joubert Syndrome Identifies a Locus on Chromosome 9q34.3 and Evidence for Genetic Heterogeneity  Kathrin Saar, Lihadh.
Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs  Jian Huang, Yanming Jiang  The.
A Novel Linkage to Generalized Vitiligo on 4q13-q21 Identified in a Genomewide Linkage Analysis of Chinese Families  Jian-Jun Chen, Wei Huang, Jin-Ping.
Genome-wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26  Axel M. Hillmer, Antonia Flaquer, Sandra.
Mark Gibbs, Janet L. Stanford, Gail P
Presentation transcript:

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting  Ari Karason, Johann E. Gudjonsson, Ruchi Upmanyu, Arna A. Antonsdottir, Valdimar B. Hauksson, E. Hjaltey Runasdottir, Hjortur H. Jonsson, Daniel F. Gudbjartsson, Michael L. Frigge, Augustine Kong, Kari Stefansson, Helgi Valdimarsson, Jeffrey R. Gulcher  The American Journal of Human Genetics  Volume 72, Issue 1, Pages 125-131 (January 2003) DOI: 10.1086/345646 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Genome scan of 39 families with PsA with 1,000-microsatellite framework marker set, in addition to the fine mapping markers in all locations of interest. The multipoint LOD score is shown on the vertical axis; the distance from the p-terminal end of the chromosome (in cM) is shown on the horizontal axis. The American Journal of Human Genetics 2003 72, 125-131DOI: (10.1086/345646) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Linkage result of 39 families on chromosome 16 with additional markers and considering paternal transmissions only (black line) and maternal transmissions only (red line). The multipoint LOD score is shown on the vertical axis; the distance from the p-terminal end of the chromosome (in cM) is shown on the horizontal axis. The American Journal of Human Genetics 2003 72, 125-131DOI: (10.1086/345646) Copyright © 2003 The American Society of Human Genetics Terms and Conditions