Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity Thomas W. Wakefield, M.D., Walter.

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Presentation transcript:

Depressed cardiovascular function and altered platelet kinetics following protamine sulfate reversal of heparin activity Thomas W. Wakefield, M.D., Walter M. Whitehouse, M.D., James C. Stanley, M.D. Journal of Vascular Surgery Volume 1, Issue 2, Pages 346-355 (March 1984) DOI: 10.1016/0741-5214(84)90067-3 Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Mean arterial blood pressure response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Cardiac output response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Superior mesenteric artery flow response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Femoral artery flow response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Femoral artery resistance changes in response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Portal venous pressure response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 7 Pulmonary capillary wedge pressure response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 8 Pulmonary vascular resistance changes in response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 9 Coronary artery flow response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 10 Changes in total peripheral resistance in response to rapid intravenous and intra-arterial administration of protamine sulfate in group I animals. Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 11 Mean arterial blood pressure changes in response to rapid intravenous administration of protamine sulfate with and without protamine sulfate pretreatment (0.75 mg/kg) prior to heparinization (groups II and III). Journal of Vascular Surgery 1984 1, 346-355DOI: (10.1016/0741-5214(84)90067-3) Copyright © 1984 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions