Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep M.A. Cake, R.A. Read, G. Corfield,

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Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep M.A. Cake, R.A. Read, G. Corfield, A. Daniel, D. Burkhardt, M.M. Smith, C.B. Little Osteoarthritis and Cartilage Volume 21, Issue 1, Pages 226-236 (January 2013) DOI: 10.1016/j.joca.2012.10.001 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Composite plots of mean, normalised vertical GRFs as a proportion of BW at 2.5, 8 and 12 weeks post-surgery, by treatment group. Dashed lines indicate baseline values; n = 4 sheep per group. Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Plots of (a) PVF, and (b) IMP vs weeks post-surgery, in the operated (R) leg after complete MX (○), cranial pole meniscal release (□), or mid-body meniscal transection (▵). Data are percentage ± 95% confidence interval (CI) of paired baseline values. Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Representative images of in situ meniscal remnants 12 weeks after MX, mid-body meniscal transection (MBT), or cranial pole meniscal release (CPR). Asterisks (*) indicate gelatinous “meniscoid” regrowth after MX, and spanning the distracted defect after MBT. Medial movement of the cranial pole after CPR appeared to be minimal (arrow). Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Composite overlays combining the areas of visible cartilage erosion on the medial tibial condyle after MX, mid-body meniscal transection (MBT), or cranial pole meniscal release (CPR). Lesions after CPR appeared to be more likely to be restricted to the cranial half of the condyle, while lesions after MX appeared more widespread. Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 X–Y plot of modified Mankin-type vs Pritzker histopathology scores, for MFC and MTP cartilage. The lines of best fit (solid line) and theoretical intersection of maxima and minima (dotted line) are indicated. Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Examples of medial tibial condyle histopathology from each treatment group. Note the degree of variation in cellularity and matrix proteoglycan loss, concomitant with only minor structural damage. Mankin-type (0–29) and Pritzker (0–24) scores are A: 4 and 4.5; B: 10 and 6; C: 17 and 15.75; D: 17.5 and 16 respectively. Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 7 Immunostaining of cartilage from each treatment group for: the ADAMTS-generated aggrecan neoepitope NITEGE (A–D); the MMP-generated aggrecan neoepitope DIPEN (F–I); and MMP-13 (K–N). The images show staining in the full depth of cartilage from the region of the MTP protected by the meniscus where the cartilage lesion develops (Fig. 6; approximately one-third of the distance from the abaxial joint margin), and are representative of three replicates from each group (Sham = arthrotomy alone, CPR = cranial pole meniscal release, MBT = mid-body meniscal transection). Negative controls (E, J, O) were stained with a species-matched IgG. The chevron shows the location of the tidemark between calcified (below) and non-calcified cartilage in each section. All images are at the same magnification, the scale bar in E = 100 μ. Osteoarthritis and Cartilage 2013 21, 226-236DOI: (10.1016/j.joca.2012.10.001) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions