H2S to Mitigate Vascular Aging: A SIRT1 Connection

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H2S to Mitigate Vascular Aging: A SIRT1 Connection Thiruma V. Arumugam, Brian K. Kennedy Cell Volume 173, Issue 1, Pages 8-10 (March 2018) DOI: 10.1016/j.cell.2018.03.011 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Mechanisms by which Exogenous H2S and Nutrient Restriction Reverse Vascular Aging Nutrient deprivation (M&C) increases VEGF via the amino-acid-sensing eIF2α kinase GCN2 and the transcription factor ATF4. GCN2/ATF4 activation increases CGL expression and H2S production. H2S boosts glucose uptake and glycolysis. Exogenous H2S promotes NAD+/SIRT1-dependent VEGF production. Collectively, this leads to EC proliferation, migration, and angiogenesis, as well as reversal of vascular aging. Of note, the link between intracellular H2S production and its action in other cells in an exogenous manner is unknown at the moment. Cell 2018 173, 8-10DOI: (10.1016/j.cell.2018.03.011) Copyright © 2018 Elsevier Inc. Terms and Conditions