Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting:

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Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting: Results of the EXPEDITION Study Robert M. Mentzer, MD, Claus Bartels, MD, Roberto Bolli, MD, Steven Boyce, MD, Gerald D. Buckberg, MD, Bernard Chaitman, MD, Axel Haverich, MD, John Knight, MD, Philippe Menasché, MD, M. Lee Myers, MD, Jose Nicolau, MD, Maarten Simoons, MD, Lars Thulin, MD, Richard D. Weisel, MD The Annals of Thoracic Surgery Volume 85, Issue 4, Pages 1261-1270 (April 2008) DOI: 10.1016/j.athoracsur.2007.10.054 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Proportion of patients experiencing the composite endpoint of death or nonfatal myocardial infarction (MI) in the placebo group (white bars [n = 2,891]) and cariporide-treated group (black bars [n = 2,870]). The EXPEDITION trial achieved primary endpoint by demonstrating a significant reduction in the incidence of death or nonfatal MI after coronary artery bypass graft surgery. The Annals of Thoracic Surgery 2008 85, 1261-1270DOI: (10.1016/j.athoracsur.2007.10.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Time to death or nonfatal myocardial infarction (MI) in the placebo and cariporide groups. The divergence in the postoperative incidence of death/nonfatal MI occurred primarily within the first 3 days of treatment. The Annals of Thoracic Surgery 2008 85, 1261-1270DOI: (10.1016/j.athoracsur.2007.10.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Cariporide treatment and incidence of nonfatal myocardial infarction (MI) after coronary artery bypass graft surgery. (White bars = placebo [n = 2,891]; black bars = cariporide-treated group [n = 2,870]). Inhibition of the sodium hydrogen exchanger (NHE) was associated with a markedly significant reduction in MI after coronary artery bypass graft surgery. The Annals of Thoracic Surgery 2008 85, 1261-1270DOI: (10.1016/j.athoracsur.2007.10.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Cariporide treatment and effect on mortality after coronary artery bypass graft surgery. (White bars = placebo [n = 2,891]; black bars = cariporide-treated group [n = 2,870]). The Annals of Thoracic Surgery 2008 85, 1261-1270DOI: (10.1016/j.athoracsur.2007.10.054) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions