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Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, Volume 40, Issue 17, 28 December 2018, Pages 1342–1351, https://doi.org/10.1093/eurheartj/ehy834 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 1 Echocardiographic still frames of patients with degenerative and rheumatic mitral stenosis. Rheumatic mitral ... Figure 1 Echocardiographic still frames of patients with degenerative and rheumatic mitral stenosis. Rheumatic mitral stenosis is characterized by commissural fusion, chordal shortening and fusion, and leaflet thickening or restricted leaflet motion due to extensive calcification (A–D). Degenerative mitral stenosis is characterized by annular calcification in combination with leaflet thickening and/or calcification, and restriction of leaflet motion without commissural fusion (E–H). Blue arrows indicate commissural fusion. Red arrows indicate leaflet thickening due to extensive calcification. Orange arrows indicate mitral annular calcification. Yellow arrows indicate absence of commissural fusion. Green arrows indicate annular calcification in combination with leaflet calcification. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, Volume 40, Issue 17, 28 December 2018, Pages 1342–1351, https://doi.org/10.1093/eurheartj/ehy834 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 A flowchart of patients included in the present analysis. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, Volume 40, Issue 17, 28 December 2018, Pages 1342–1351, https://doi.org/10.1093/eurheartj/ehy834 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 The Kaplan–Meier curve of (A) cardiovascular death and (B) disabling stroke for patients with concomitant ... Figure 3 The Kaplan–Meier curve of (A) cardiovascular death and (B) disabling stroke for patients with concomitant mitral stenosis (blue) and without mitral stenosis (red). Landmark analysis at 30 days of (C) cardiovascular death and (D) disabling stroke for patients with concomitant mitral stenosis (blue) and without mitral stenosis (red). Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, Volume 40, Issue 17, 28 December 2018, Pages 1342–1351, https://doi.org/10.1093/eurheartj/ehy834 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4 Bar graph illustrating disabling stroke and cardiovascular death in (A) patients with no, mild, and ... Figure 4 Bar graph illustrating disabling stroke and cardiovascular death in (A) patients with no, mild, and moderate/severe mitral stenosis and (B) patients with no, degenerative, and rheumatic mitral stenosis at 1 year. <sup>a</sup>Adjusted hazard ratios (95% confidence intervals). Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, Volume 40, Issue 17, 28 December 2018, Pages 1342–1351, https://doi.org/10.1093/eurheartj/ehy834 The content of this slide may be subject to copyright: please see the slide notes for details.

Take home figure The Kaplan–Meier curve of cardiovascular death. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, Volume 40, Issue 17, 28 December 2018, Pages 1342–1351, https://doi.org/10.1093/eurheartj/ehy834 The content of this slide may be subject to copyright: please see the slide notes for details.