Figure 1 Differential effects of bone-forming agents on bone surfaces

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Presentation transcript:

Figure 1 Differential effects of bone-forming agents on bone surfaces Figure 1 | Differential effects of bone-forming agents on bone surfaces. Teriparatide and abaloparatide act primarily by activating bone formation coupled to bone resorption at remodelling surfaces, and to a lesser extent by activating quiescent bone-forming cells at modelling surfaces. Romosozumab acts primarily by activating modelling-based bone formation while inhibiting bone resorption at remodelling surfaces. Ferrari, S. L. (2018) Romosozumab to rebuild the foundations of bone strength Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2018.5