Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate Matthew Remedios,

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Presentation transcript:

Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate Matthew Remedios, MBBS, Catherine Campbell, MBBS, Dianne M. Jones, B App Sc, Paul Kerlin, MD Gastrointestinal Endoscopy Volume 63, Issue 1, Pages 3-12 (January 2006) DOI: 10.1016/j.gie.2005.07.049 Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 A, Linear furrows in esophageal lumen. B, Mucosal rings. C, Multiple white papules/plaques in esophagus. D, Histologic appearance of esophageal biopsy specimens, demonstrating markedly increased intraepithelial eosinophils. (H&E, orig. mag. ×100). Gastrointestinal Endoscopy 2006 63, 3-12DOI: (10.1016/j.gie.2005.07.049) Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 A, Linear furrows in esophageal lumen. B, Mucosal rings. C, Multiple white papules/plaques in esophagus. D, Histologic appearance of esophageal biopsy specimens, demonstrating markedly increased intraepithelial eosinophils. (H&E, orig. mag. ×100). Gastrointestinal Endoscopy 2006 63, 3-12DOI: (10.1016/j.gie.2005.07.049) Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 A, Linear furrows in esophageal lumen. B, Mucosal rings. C, Multiple white papules/plaques in esophagus. D, Histologic appearance of esophageal biopsy specimens, demonstrating markedly increased intraepithelial eosinophils. (H&E, orig. mag. ×100). Gastrointestinal Endoscopy 2006 63, 3-12DOI: (10.1016/j.gie.2005.07.049) Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 1 A, Linear furrows in esophageal lumen. B, Mucosal rings. C, Multiple white papules/plaques in esophagus. D, Histologic appearance of esophageal biopsy specimens, demonstrating markedly increased intraepithelial eosinophils. (H&E, orig. mag. ×100). Gastrointestinal Endoscopy 2006 63, 3-12DOI: (10.1016/j.gie.2005.07.049) Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 2 Symptom score before and after treatment with swallowed fluticasone propionate. Cumulative symptom score based on presence and frequency of dysphagia, chest pain, heartburn, regurgitation, vomiting, and abdominal pain (each scored 0 to 3). Gastrointestinal Endoscopy 2006 63, 3-12DOI: (10.1016/j.gie.2005.07.049) Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions

Figure 3 Mean eosinophils/HPF in proximal and distal esophageal biopsy specimens before and after treatment with swallowed fluticasone propionate. Gastrointestinal Endoscopy 2006 63, 3-12DOI: (10.1016/j.gie.2005.07.049) Copyright © 2006 American Society for Gastrointestinal Endoscopy Terms and Conditions