Histological Scoring for Small Lung Adenocarcinomas 2 cm or Less in Diameter: A Reliable Prognostic Indicator Akiko Miyagi Maeshima, MD, Naobumi Tochigi,

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Histological Scoring for Small Lung Adenocarcinomas 2 cm or Less in Diameter: A Reliable Prognostic Indicator Akiko Miyagi Maeshima, MD, Naobumi Tochigi, MD, Akihiko Yoshida, MD, Hisao Asamura, MD, Koji Tsuta, MD, Hitoshi Tsuda, MD Journal of Thoracic Oncology Volume 5, Issue 3, Pages 333-339 (March 2010) DOI: 10.1097/JTO.0b013e3181c8cb95 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Histology of Sakurai grades 1 and 2 and a histologic score 3 tumor. A, Sakurai grade 1 resembles bronchioloalveolar carcinoma (BAC) in low-power view (hematoxylin and eosin [HE], ×40). B, Sakurai grade 1 has a small invasive focus in the alveolar area (HE, ×400). C, Sakurai grade 2 resembles BAC with collapse in low-power view (HE, ×40). D, Sakurai grade 2 shows a fibroblastic reaction only at the interface between BAC and collapse (HE, ×200). E, F, An example of a score 3 tumor. The tumor shows non-BAC >10 mm, %solid/cribriform/papillary ≧30% (E, HE, ×12.5), and lymphovascular invasion positivity (F, HE, ×100). Both scar and a papillary component were counted as non-BAC. Journal of Thoracic Oncology 2010 5, 333-339DOI: (10.1097/JTO.0b013e3181c8cb95) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Survival curves for all 510 patients stratified by histologic score. Journal of Thoracic Oncology 2010 5, 333-339DOI: (10.1097/JTO.0b013e3181c8cb95) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Survival curves for 242 patients with overtly invasive adenocarcinomas stratified by histologic score. Journal of Thoracic Oncology 2010 5, 333-339DOI: (10.1097/JTO.0b013e3181c8cb95) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions