The validity of in vitro ultrasonographic grading of osteoarthritic femoral condylar cartilage – a comparison with histologic grading C.-Y. Tsai, M.D.,

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The validity of in vitro ultrasonographic grading of osteoarthritic femoral condylar cartilage – a comparison with histologic grading C.-Y. Tsai, M.D., C.-L. Lee, M.D., M.S., C.-Y. Chai, M.D., Ph.D., C.-H. Chen, M.D., J.-Y. Su, M.D., H.-T. Huang, M.D., M.-H. Huang, M.D., Ph.D. Osteoarthritis and Cartilage Volume 15, Issue 3, Pages 245-250 (March 2007) DOI: 10.1016/j.joca.2006.08.009 Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Two transverse areas, anterior (arrowheads) and middle (white arrows), were chosen on both medial and lateral condyle specimens for US examination. Then they were marked with gentian violet for localization of histologic examination. Osteoarthritis and Cartilage 2007 15, 245-250DOI: (10.1016/j.joca.2006.08.009) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 US grading of OA cartilage. Grade 1: homogeneously anechoic band with sharp margin. Grade 2: blurring or obliteration of the margin. Grade 3: blurring, obliteration of margin and narrowing of cartilage band. Grade 4: cartilage band cannot be visualized. Osteoarthritis and Cartilage 2007 15, 245-250DOI: (10.1016/j.joca.2006.08.009) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 The histologic grading and characteristics of OA cartilage. Grade 1: flaking (A) and superficial fibrillation (B). Grade 2: chondrocyte enlargement (C) and hyalinization (D). Grade 3: deep fibrillation (E) and pitting (F). Grade 4: partial cartilage loss (G) or complete cartilage loss (H). HE stain, 40×. Osteoarthritis and Cartilage 2007 15, 245-250DOI: (10.1016/j.joca.2006.08.009) Copyright © 2006 Osteoarthritis Research Society International Terms and Conditions