Inside the Chamber of Secrets of the Type III Secretion System

Slides:

Advertisements

Similar presentations

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker Ernesto Arias-Palomo, Valerie L. O’Shea, Iris V. Hood, James M. Berger Cell Volume 153, Issue.

Advertisements

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E Yumi Kim, Andrew J. Holland, Weijie Lan, Don W. Cleveland.

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry Xing Zhang, Lei Jin, Qin Fang, Wong H. Hui, Z. Hong Zhou Cell.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity Jean-Baptiste Vannier, Visnja Pavicic-Kaltenbrunner, Mark I.R.

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles Sandra E. Encalada, Lukasz Szpankowski, Chun-hong Xia,

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Gemmata obscuriglobus

Lights, X-Rays, Oxygen! Cell

New Ways to Make Old Walls: Bacterial Surprises

Nuclear envelope Current Biology

ChIP-Seq Data Reveal Nucleosome Architecture of Human Promoters

Volume 9, Issue 2, Pages (August 2011)

Volume 23, Issue 3, Pages (April 2018)

Microbiology: And Amoebophilus Invented the Machine Gun!

Redefining Clinical Trials: The Age of Personalized Medicine

Volume 159, Issue 5, Pages (November 2014)

GroEL: More than Just a Folding Cage

A View to a Kill: Structure of the RNA Exosome

Mitochondrial Matrix Reloaded with RNA

In This Issue Cell Volume 158, Issue 5, (August 2014)

Putting the Balance Back in Diet

Unraveling Cell-Cycle Dynamics in Cancer

ESCRTs Take on a Job in Surveillance

Imaging the Neural Basis of Locomotion

The Turn of the Screw: The Bacterial Flagellar Motor

Volume 152, Issue 1, (January 2013)

Stephen P. Muench, Martin van der Laan Molecular Cell

Retromer Sets a Trap for Endosomal Cargo Sorting

Volume 130, Issue 6, (September 2007)

Course of Protochlamydia type III secretion system activity during the developmental cycle. Course of Protochlamydia type III secretion system activity.

Picking Pyknons out of the Human Genome

Protein-Injection Machines in Bacteria

When Biology Doesn’t Add Up

Volume 143, Issue 6, (December 2010)

Bacterial Adhesins in Host-Microbe Interactions

Iron Sensing as a Partnership: HFE and Transferrin Receptor 2

Both Layers of the COPII Coat Come into View

The Plasticity of Aging: Insights from Long-Lived Mutants

Tuning Bulk Electrostatics to Regulate Protein Function

Learning from the Uncontrollable

Coordination of Two Genomes by Mitochondrial Translational Plasticity

Microbiology: And Amoebophilus Invented the Machine Gun!

ChIP-Seq Data Reveal Nucleosome Architecture of Human Promoters

Volume 163, Issue 4, (November 2015)

Volume 163, Issue 2, (October 2015)

Navigating the Deubiquitinating Proteome with a CompPASS

Pleckstrin Homology Domains: Two Halves Make a Hole?

Volume 134, Issue 6, (September 2008)

Cryo-EM Captures the Dynamics of Ion Channel Opening

In This Issue Cell Volume 145, Issue 3, (April 2011)

The T3SS apparatus consists of rings that provide a continuous path across the inner (IM) and outer (OM) bacterial membranes, including the peptidoglycan.

Volume 148, Issue 1, (January 2012)

Targeting Protein Stability with a Small Molecule

Presentation transcript:

Inside the Chamber of Secrets of the Type III Secretion System Eric Cascales Cell Volume 168, Issue 6, Pages 949-951 (March 2017) DOI: 10.1016/j.cell.2017.02.028 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Architecture of the Salmonella Type III Secretion Injectisome (A) Schematic representation of a Salmonella cell with assembled SPI-1 type III secretion systems. A magnification of the secretion apparatus is shown in (B). (B) Architecture of the Salmonella type III secretion system’s (T3SS’s) injectisome, as revealed by cryo-ET. The localizations of the different subunits (see color code on left) are indicated: OM, outer membrane; PG, peptidoglycan; IM, inner membrane; OR, outer ring; IR, inner ring; CP, cytoplasmic platform. For each protein, the unified T3SS Sct nomenclature is indicated, as well as the name of the orthologs in Yersinia (Ysc), Shigella (Spa/Mxi), Salmonella (Inv/Prg/Org), and the flagellum (Fli, Flh). The dash denotes absence of orthologs. Cell 2017 168, 949-951DOI: (10.1016/j.cell.2017.02.028) Copyright © 2017 Elsevier Inc. Terms and Conditions