Two channels for one job

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Two channels for one job S.C. Sansom, P.A. Welling Kidney International Volume 72, Issue 5, Pages 529-530 (September 2007) DOI: 10.1038/sj.ki.5002438 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Illustration of the separate roles of BK and ROMK in the distal nephron. ROMK channels are located in principal cells (PCs) of the distal nephron, which includes the connecting tubule and the cortical collecting duct. BK channels are located in both PCs and intercalated cells (ICs). However, the role of BK in ICs is uncertain, as Na-K-ATPase is minimal in these cells. Although BK and ROMK are primarily known as ‘flow-dependent’ and ‘constitutive’ K secretory channels, respectively, studies using BK–/– and ROMK–/– mice indicate that these channels may have some redundant roles during the various demands for K secretion. Kidney International 2007 72, 529-530DOI: (10.1038/sj.ki.5002438) Copyright © 2007 International Society of Nephrology Terms and Conditions