Gene expression analysis of OA synovium reveals elevation of TGF-ß responsive genes in OA-related fibrosis D.F. Remst, A.B. Blom, E.N. Blaney Davidson,

Slides:

Advertisements

Similar presentations

Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling W. Madej, A. van Caam, E.N. Blaney Davidson, P.M.

Advertisements

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1 A. van Caam, E. Blaney Davidson, A.

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression.

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state N. Fahy, M.L. de Vries-van.

The epidemiology and impact of pain in osteoarthritis

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung

M. H. van den Bosch, A. B. Blom, V. Kram, A. Maeda, S. Sikka, Y

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

High LDL levels lead to increased synovial inflammation and accelerated ectopic bone formation during experimental osteoarthritis W. de Munter, M.H.

Bone Morphogenetic Proteins and articular cartilage

Osteoarthritis year in review 2016: biology

Osteoarthritis and Cartilage

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Exploring longitudinal associations of histologically assessed inflammation with symptoms and radiographic damage in knee osteoarthritis: combined results.

Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes M. Qadri, R. Ostrom, K.A. Elsaid Osteoarthritis.

Synovial macrophages promote TGF-β signaling and protect against influx of S100A8/S100A9-producing cells after intra-articular injections of oxidized.

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

Osteoarthritis and Cartilage

Osteoarthritis pain mechanisms: basic studies in animal models

The effect of conditional macrophage depletion on development of injury-induced knee OA in obese transgenic MAFIA mice C.-L. Wu, J. McNeill, K. Goon,

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis S.C.M. van Dalen, A.B. Blom, A.W.

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

Time to be positive about negative data?

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

The S100A9 inhibitor paquinimod (ABR ) reduces synovial activation, osteophyte formation and cartilage damage in experimental osteoarthritis R.F.

TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5- Smad2/3 pathway. Potential role in OA related pain? E.N. Blaney.

Gene expression variation in human meniscus: molecular and clinical implications for cartilage homeostasis and early osteoarthritis development M.F.

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes

Mice with global deletion of mitogen inducible gene 6 display rapid and severe cartilage and subchondral bone damage after ligament and meniscus injury

Different responses of healthy, relative healthy and OA chondrocytes with IL1β treatment under hypoxia and normoxia X. Huang, L. Zhong, J. Post, M. Karperien

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Effect of soft braces on pain and physical function in patients with knee osteoarthritis: systematic review with meta-analyses T. Cudejko, M. van der.

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

T. J. Hoogeboom, C. H. M. van den Ende, G. van der Sluis, J. Elings, J

M.L. Roemhildt, A.E. Gauthier Osteoarthritis and Cartilage

M. F. Pustjens, S. C. Mastbergen, W. H. Noort-Van der Laan, R. J

Osteoarthritis and Cartilage

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

D.J. Hunter Osteoarthritis and Cartilage

G. van den Akker, T. Welting, D. Surtel, A. Cremers, W. Voncken, L

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression D.F.G. Remst,

Bone Morphogenetic Proteins and articular cartilage

N. Takahashi, Ph. D. , K. Rieneck, M. D. , P. M. van der Kraan, Ph. D

Osteoarthritis and Cartilage

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

S.G. Muthuri, D.F. McWilliams, M. Doherty, W. Zhang

Novel juvenile factors for cartilage regeneration

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

WNT and WISP1 expression in the synovium induces production of cartilage-degrading metalloproteinases by synovial cells M.H. van den Bosch, A.B. Blom,

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

Osteoarthritis year 2012 in review: biology

No treatment effects of oral glucosamine for subgroups of knee and hip osteoarthritis patients; an individual patient data meta-analysis from the OA trial.

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Osteoarthritis and Cartilage

Arthritic synovial fluid influences expression of pro- and anti-inflammatory mediators in macrophages S. Lopa, M. Leijs, M. Moretti, E. Lubberts, G.

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Gene expression analysis of OA synovium reveals elevation of TGF-ß responsive genes in OA-related fibrosis D.F. Remst, A.B. Blom, E.N. Blaney Davidson, E.L. Vitters, R.A. Bank, W.B. van den Berg, P.M. van der Kraan Osteoarthritis and Cartilage Volume 21, Pages S285-S286 (April 2013) DOI: 10.1016/j.joca.2013.02.598 Copyright © 2013 Terms and Conditions

Fig 1. Fibrotic genes that are at least 2-fold upregulated in TGF-β stimulated OA fibroblasts, synovium of mice with collagenase-induced OA and in synovium obtained from patients with end stage OA. Osteoarthritis and Cartilage 2013 21, S285-S286DOI: (10.1016/j.joca.2013.02.598) Copyright © 2013 Terms and Conditions