Volume 15, Issue 14, Pages 1257-1265 (July 2005) Positive Selection on a High-Sensitivity Allele of the Human Bitter-Taste Receptor TAS2R16  Nicole Soranzo, Bernd Bufe, Pardis C. Sabeti, James F. Wilson, Michael E. Weale, Richard Marguerie, Wolfgang Meyerhof, David B. Goldstein  Current Biology  Volume 15, Issue 14, Pages 1257-1265 (July 2005) DOI: 10.1016/j.cub.2005.06.042 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 TAS2R16 Allele and Haplotype Frequency Distribution in the Worldwide Sample (A) Haplotype network for the four common haplotypes; the size of each pie chart is proportional to the total number of haplotypes; pie segments indicate main continents. (B and C) Worldwide frequency distribution of the two ancestral variants K172 (B) and H222 (C) are shown. Current Biology 2005 15, 1257-1265DOI: (10.1016/j.cub.2005.06.042) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 Functional Analyses of the TAS2R16 Variants in HEK293 Cells (A) Intracellular-calcium traces of the TAS2R16 constructs N172/R222 and K172/R222, as well as mock-transfected control cells recorded in the FLIPR experiment upon stimulation with seven structurally divergent compounds, are shown. The scale bar denotes 2000 relative light units and 1 min. (B) Concentration-response relations of cells transfected with different TAS2R16 constructs upon stimulation with salicin, arbutin, or amygdalin are shown. Current Biology 2005 15, 1257-1265DOI: (10.1016/j.cub.2005.06.042) Copyright © 2005 Elsevier Ltd Terms and Conditions