Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients Ariel Israel, MD, PhD, Ehud Grossman, MD The.

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Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients Ariel Israel, MD, PhD, Ehud Grossman, MD The American Journal of Medicine Volume 130, Issue 11, Pages 1324.e7-1324.e13 (November 2017) DOI: 10.1016/j.amjmed.2017.05.030 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Receiver operator characteristic curves (ROC) for gradient boosting models predicting the risk of future hyponatremia using baseline participant characteristics: the red curve describes the full model, the black curve describes a model that was trained without some variables from the lipid profile (high-density lipoprotein, total cholesterol, and triglycerides). The vertical lines give the false positive rate for the predetermined sensitivity of 50%. AUC = area under the curve. The American Journal of Medicine 2017 130, 1324.e7-1324.e13DOI: (10.1016/j.amjmed.2017.05.030) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Density plots comparing high-density lipoprotein cholesterol (HDL-C) at baseline in Systolic Blood Pressure Intervention Trial (SPRINT) participants who developed hyponatremia (red) during the study and patients who did not develop hyponatremia (blue). Baseline HDL-C was significantly more elevated in participants who later developed hyponatremia, for both males and females (P <.0001 in both sexes; Wilcoxon test). The American Journal of Medicine 2017 130, 1324.e7-1324.e13DOI: (10.1016/j.amjmed.2017.05.030) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 3 Kaplan-Meier plots comparing the occurrence of hyponatremia events for patients in the highest high-density lipoprotein cholesterol (HDL-C) quintile, with the rest of the patients, both in the standard treatment arm (A) and the intensive treatment arm (B). The American Journal of Medicine 2017 130, 1324.e7-1324.e13DOI: (10.1016/j.amjmed.2017.05.030) Copyright © 2017 Elsevier Inc. Terms and Conditions