RNA Virus Harnesses MicroRNAs to Seize Host Translation Control

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RNA Virus Harnesses MicroRNAs to Seize Host Translation Control Teresa M. Abraham, Peter Sarnow Cell Host & Microbe Volume 9, Issue 1, Pages 5-7 (January 2011) DOI: 10.1016/j.chom.2011.01.004 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Picornavirus Strategies to Inhibit Cap-dependent Translation (A) Picornavirus infection results in sequestration of eIF4E and cleavage of factors eIF4G and PABP. See text for details. (B) Infection by enterovirus 71 (EV71), poliovirus 3 (PV3) or coxsackievirus B3 (CVB3) upregulates the transcription factor, EGR1, which results in increased expression of primary miR-141 transcript and mature miR-141. Mature miR-141 binds to the 3′ UTR of eIF4E mRNA and suppresses protein synthesis. Cell Host & Microbe 2011 9, 5-7DOI: (10.1016/j.chom.2011.01.004) Copyright © 2011 Elsevier Inc. Terms and Conditions