DENERHTN Trial design: Patients with resistant hypertension were randomized to renal denervation plus standardized stepped-care antihypertensive treatment (n = 53) vs. standardized stepped-care antihypertensive treatment alone (n = 53). (p = 0.033) Results Change in systolic blood pressure from baseline to 6 months: -15.8 mm Hg in the renal denervation group vs. -9.9 mm Hg in the standardized antihypertensive treatment alone group (p = 0.033) Change in SBP mm Hg -9.9 Conclusions Among patients with resistant hypertension, renal denervation plus standardized antihypertensive treatment was more effective at reducing ambulatory, but not office blood pressure, compared with standardized antihypertensive treatment alone -15.8 Anti-hypertensive treatment alone Renal denervation Azizi M, et al., Lancet 2015;385:1957-65