Both Retinoic Acid Receptors α (RARα) and γ (RARγ) Are Able to Initiate Mouse Upper- Lip Skin Glandular Metaplasia Sandrine Blanchet, Bertrand Favier,

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Both Retinoic Acid Receptors α (RARα) and γ (RARγ) Are Able to Initiate Mouse Upper- Lip Skin Glandular Metaplasia Sandrine Blanchet, Bertrand Favier, Geneviève Chevalier, Jean-Jacques Michaille, Danielle Dhouailly Journal of Investigative Dermatology Volume 111, Issue 2, Pages 206-212 (August 1998) DOI: 10.1046/j.1523-1747.1998.00275.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Distribution pattern of mouse WT upper-lip hair vibrissæ. (A) Isolated epidermis from a 13.5 d embryo, showing five rows of vibrissa anlagen from placodal (PA) to hair peg (PG) stages. Osmium tetroxyde fixation. Scale bar, 200 μm. (B) Tangential and partial section of a control 13.5 d explant after 48 h in vitro followed by 10 d onto nude mice kidney: differentiation of three rows of hair vibrissa follicles (VF), intermingled with numerous hair pelage follicles (HP). Hematoxylin/Biebrich scarlet staining. Scale bar, 100 μm. D/V, dorso/ventral; O/N, ocular/nasal. Journal of Investigative Dermatology 1998 111, 206-212DOI: (10.1046/j.1523-1747.1998.00275.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 tRA induces a hair vibrissa metaplasia in mouse upper-lip skin explants from WT embryos as well as from RARα–/–, β–/–, or γ–/– null mutants. Upper-lip skin explants from 13.5 d embryos were cultured in vitro for 2 d in the absence (–RA) or the presence (+RA) of 16.5 μM tRA. They were then grafted onto nude mice kidney for 10 d. Untreated WT (A) as well as RARα–/– (C), RARβ–/– (E), and RARγ–/– (G) explants developed normal vibrissa and pelage hair follicles. After tRA treatment, similar glandular structures were observed in WT (B), RARα–/– (D), RARβ–/– (F), and RARγ–/– (H) explants. (A–F) Longitudinal sections. (G, H) Transversal sections. AGG, Glomerular gland associated with a vibrissa; DC, duct; DP, dermal papilla; E, epidermis; GG, glomerular gland; HP, hair pelage follicle; HS, hair shaft; IRS, inner root sheath; L, lumen; ORS, outer root sheath; SG, sebaceous gland; VF, hair vibrissa follicle. (A–H) Hematoxylin/Biebrich scarlet staining. Scale bar, 100 μm. Journal of Investigative Dermatology 1998 111, 206-212DOI: (10.1046/j.1523-1747.1998.00275.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 RARγ knockout dramatically decreases the response totRA treatment. Bars represent the percentage of vibrissæ that were transformed into glands in explants of 13.5 d WT, RARα–/–, RARβ–/–, or RARγ–/– embryos treated for 2 d with 16.5 μM tRA and processed as in Figure 2. Error bars, mean ± SD. Journal of Investigative Dermatology 1998 111, 206-212DOI: (10.1046/j.1523-1747.1998.00275.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 The activation of more than one RAR is required to reach the highest ratios of vibrissa metaplasia. WT explants were treated with (A) the CD367 RAR pan-agonist; (B) the Ro25–7386 RXR pan-agonist; (C) Ro40–6055, believed to be RARα-specific at 8 × 10–3μM; (D) CD437, believed to be RARγ-specific at 7.7 × 10–2μM. Bars represent the percentages of vibrissæ transformed into glands in WT 13.5 d upper-lip skin explants treated for 2 d with the indicated retinoid and processed as in Figure 2. Concentrations are given in μM. Error bars, mean ± SD. Journal of Investigative Dermatology 1998 111, 206-212DOI: (10.1046/j.1523-1747.1998.00275.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Treatment with a RAR pan-agonist induces not only a hair vibrissa metaplasia, but also a sebaceous gland hypertrophy. Explants of 13.5 d upper-lip skin were treated for 2 d with the CD367 RAR pan-agonist (10–3μM) and processed as in Figure 2. (A) Overview showing several glomerular glands associated with GSG and a complete disappearance of hair vibrissa follicles. Only some hair pelage follicles (HP) are formed (compare with the control, Figure 1b). (B) Detail of a glomerular gland with a branched duct (BDC) and secretories elements (SE). (C) Detail of a GSG. G, Glomerule; L, lumen. (A–C) Hematoxylin/Biebrich scarlet staining. Scale bar, 100 μm. Journal of Investigative Dermatology 1998 111, 206-212DOI: (10.1046/j.1523-1747.1998.00275.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions