An ECHO in biology II: Insights in chondrocyte cell fate

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Presentation transcript:

An ECHO in biology II: Insights in chondrocyte cell fate S. Schivo, J. Scholma, X. Huang, L. Zhong, J. van de Pol, M. Karperien, R. Langerak, J.N. Post Osteoarthritis and Cartilage Volume 24, Pages S176-S177 (April 2016) DOI: 10.1016/j.joca.2016.01.347 Copyright © 2016 Terms and Conditions

Figure 1 Dose-dependent effects of extra-cellular ligands in growth plate (GP) and articular (AC) chondrocytes. The initial activity level of each extra-cellular ligand was set at a fixed level between 0 and 100 with increments of 10 (0, 10, 20, … 100), while all other nodes were randomly initialized. After 10,000 simulations, the percentage of cell fate was recorded. Healthy AC: SOX9+, light grey; OA / hypertrophic chondrocyte: RUNX2+, dark grey. Osteoarthritis and Cartilage 2016 24, S176-S177DOI: (10.1016/j.joca.2016.01.347) Copyright © 2016 Terms and Conditions